Project Grant R01AG096488
- The National Institute on Aging awarded University of California, San Diego $165,488 on March 1, 2026, under the Aging Research program (CFDA 93.866) to reduce misdiagnosis in Alzheimer's disease through artificial intelligence-driven biomarker identification. The project constructs a comprehensive multidimensional database by repurposing over 1,500 limited-volume dementia samples using Silver-Seq, a small input liquid volume extracellular RNA sequencing technique, spanning 25 years of diverse...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded the University of Southern California $359,735 on September 1, 2026, under the Aging Research program (CFDA 93.866) for a Project Grant (R21AG091332) to develop generative artificial intelligence methods for interpretable Alzheimer's disease detection using denoising diffusion probabilistic models applied to neuroimaging. The project addresses the challenge of distinguishing brain changes attributable to Alzheimer's disease from normal age-related...
- The National Institute on Aging awarded The Leland Stanford Junior University $630,031 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop an artificial intelligence-driven metabolic clock for distinguishing healthy aging from Alzheimer's disease and Alzheimer's disease-related dementias. The project uses large-scale untargeted metabolomics to identify metabolic deviations associated with cognitive decline in aging and dementia. The research tests the hypothesis...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $682,281 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell-based three-dimensional brain tissue microsphere model that recapitulates granulin deficiency phenotypes and associated pathology in neurodegenerative diseases including frontotemporal dementia and neuronal ceroid lipofuscinosis. The model...
- The National Institute on Aging awarded $526,607 to Wake Forest University on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop computational imaging frameworks that integrate neuroimaging with multi-omics data to identify Alzheimer's disease subtypes and model neurodegenerative progression with calibrated uncertainty. The project, titled "Neuroimaging Multi-Omics Fingerprints for Subtyping and Uncertainty-Aware Prediction of Alzheimer's Disease," will...
- The National Institute on Aging, part of the National Institutes of Health, awarded $1,250,191 to the University of North Carolina at Chapel Hill on February 15, 2026, under the Aging Research program (CFDA 93.866) to develop an integrated artificial intelligence and experimental workflow for accelerating discovery of small-molecule modulators that influence Alzheimer's disease through microglial phagocytosis regulation. The funded work combines AI-driven computational methods with...
- The National Institute on Aging awarded The Leland Stanford Junior University $4.891 million on August 15, 2026, under the Aging Research program (CFDA 93.866) to establish the Stanford University Artificial Intelligence and Technology Collaboratory (SU-AITC) Center for Precision Health & Interventions in Aging and AD/ADRD. The award funds the development and deployment of artificial intelligence algorithms, scalable digital biomarkers, and cost-effective digital interventions to translate...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $129,330 on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop artificial intelligence techniques for identifying cerebral amyloid angiopathy at early disease stages using multimodal MRI sequences. The recipient will integrate accessible MRI sequences—T1-weighted, T2-weighted, T2*-weighted gradient echo, fluid-attenuated inversion recovery, and diffusion imaging—to...
- The National Institute on Aging awarded the University of Washington $575,342 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop statistical and artificial intelligence tools that elucidate cognitive resilience in Alzheimer's disease by linking region-resolved neuropathology with cell-type programs, particularly microglia function. The project integrates quantitative digital neuropathology with single-cell and spatial molecular profiles to build methods that estimate...
The National Institute on Aging awarded the University of California, Berkeley $549,260 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop advanced large language model-based AI tools that enhance precision in predicting Alzheimer's disease pathology and cognitive outcomes. The research addresses critical gaps in precision medicine for Alzheimer's disease, particularly the need to capture patient heterogeneity, accurately identify treatment candidates for FDA-approved monoclonal antibody therapies such as lecanemab and donanemab, and model disease progression trajectories accounting for factors including APOE-E4 status and tau burden. The award supports integration of high-accuracy blood biomarkers like phosphorylated tau-217 for individual risk assessment and treatment suitability in clinical practice. Work is performed in Berkeley, California through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $549.3k | 8/26/26 |