Project Grant R21AG091332
Award Date 9/1/26
Completion Date 8/31/28
Dollars Obligated $360K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
- The National Institute on Aging awarded the University of Southern California $695,789 on January 1, 2026, under the Aging Research program (CFDA 93.866) to develop HGEA-NET, a multiscale computational model of the hippocampus that integrates cell type-specific gene expression and connectivity data to understand how progressive neurodegeneration of vulnerable neuronal populations leads to hippocampal network dysfunction and cognitive decline in Alzheimer's disease. The project builds on USC's...
- The National Institute on Aging awarded the University of California, Berkeley $549,260 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop advanced large language model-based AI tools that enhance precision in predicting Alzheimer's disease pathology and cognitive outcomes. The research addresses critical gaps in precision medicine for Alzheimer's disease, particularly the need to capture patient heterogeneity, accurately identify treatment candidates for...
- The National Institute on Aging awarded the University of California, San Diego $150,512 on August 2, 2026, under the Aging Research program (CFDA 93.866) to develop and validate a novel diffusion MRI neuroimaging biomarker for early detection of Alzheimer's disease. The project focuses on microstructural changes in gray matter mean diffusivity (GMD) that may precede macrostructural atrophy visible on conventional MRI. Current AD detection relies primarily on macrostructural metrics such as...
- The National Institute on Aging awarded the University of Southern California $149,190 on August 6, 2026, under the Aging Research program (CFDA 93.866) to investigate how early-stage Alzheimer's disease disrupts coordinated release dynamics between acetylcholine and norepinephrine in the cortex and how this discoordination impairs cognitive performance. The research characterizes the evolution of coordinated cortical acetylcholine and norepinephrine release activity in vivo in wildtype mice,...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded University of California, San Diego $165,488 on March 1, 2026, under the Aging Research program (CFDA 93.866) to reduce misdiagnosis in Alzheimer's disease through artificial intelligence-driven biomarker identification. The project constructs a comprehensive multidimensional database by repurposing over 1,500 limited-volume dementia samples using Silver-Seq, a small input liquid volume extracellular RNA sequencing technique, spanning 25 years of diverse...
- Federal Grant Award Summary The National Institute on Aging awarded Columbia University's Health Sciences Division a $6.93 million Project Grant on August 1, 2025, under the Aging Research program (CFDA 93.866) to develop a multi-organ artificial intelligence-derived endophenotype (MAE) chart for personalized Alzheimer's disease and aging research. The four-year project, extending through July 31, 2029, will integrate large-scale multi-omics and multi-organ biomedical data with advanced...
- The National Institute on Aging awarded the University of California, Los Angeles $623,176 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on modifiable risk factors for Alzheimer's disease and related dementias among individuals aged 90 and older. The research triangulates evidence across four data sources—the LifeAfter90 Study (1,397 participants, all aged 90), the 90+ Study (1,630 participants, all aged 90), the Health and Retirement Study (3,359...
- The National Institute on Aging awarded $526,607 to Wake Forest University on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop computational imaging frameworks that integrate neuroimaging with multi-omics data to identify Alzheimer's disease subtypes and model neurodegenerative progression with calibrated uncertainty. The project, titled "Neuroimaging Multi-Omics Fingerprints for Subtyping and Uncertainty-Aware Prediction of Alzheimer's Disease," will...
- The National Institute on Aging awarded the University of Washington $575,342 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop statistical and artificial intelligence tools that elucidate cognitive resilience in Alzheimer's disease by linking region-resolved neuropathology with cell-type programs, particularly microglia function. The project integrates quantitative digital neuropathology with single-cell and spatial molecular profiles to build methods that estimate...