Project Grant R01AG095170
- Federal Grant Award Summary The National Institute on Aging (CFDA 93.866, Aging Research program) awarded The University of Iowa a Project Grant of $427,625 effective September 18, 2025, with completion scheduled for August 31, 2027. The award supports research investigating the relationship between cystic fibrosis transmembrane conductance regulator (CFTR) protein dysfunction and vascular endothelial function with aging. The research will utilize a novel mouse model with endothelial-specific...
- Federal Project Grant Award Summary Iowa State University of Science and Technology received a $810,310 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 1, 2025, through August 31, 2027. This research project investigates cerebral pulsatility—the discontinuous nature of blood flow in the brain—as a potential mechanism through which the menopause transition accelerates cerebrovascular aging and increases Alzheimer's...
- Federal Grant Award Summary The University of Iowa received a $462,341 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for the period May 1, 2026 through April 30, 2028. This grant supports Stage 0 and 1A research to develop the Age-Friendly Hospital-to-Home Transition Intervention (ARRIVE-at-Home), which integrates geriatric care principles into evidence-based hospital discharge transition processes. The research employs systems...
- Federal Project Grant Award Summary The University of Missouri System received a $429,394 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded December 15, 2025, with completion targeted for November 30, 2027. This research initiative investigates LARP6 (LA Ribonucleoprotein 6) as a therapeutic target for treating heart failure with preserved ejection fraction (HFpEF) in aging populations with comorbid conditions such as obesity and...
- Federal Project Grant Award Summary The University of Iowa received a $155,500 Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) for the period August 1, 2025 through July 31, 2027. The award funds research investigating the use of a superoxide dismutase (SOD) mimetic compound (rucosopasem) to mitigate age-associated, radiation-induced cardiopulmonary damage in elderly populations. The research will employ...
- Federal Project Grant Award Summary The University of Utah's Office of Sponsored Projects received a $612,346 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 1, 2026, through February 28, 2031. This collaborative research initiative investigates age-associated decline of meningeal gamma-delta T (GDT) cells and their modulation through the gut-meninges axis. The project will generate fundamental scientific discoveries...
- Federal Project Grant Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The University of Iowa a Project Grant valued at $651,009 under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 12, 2025, with completion targeted for May 31, 2029. This grant funds basic research investigating the role of junctophilin-2 (JP2) in cardiac fibroblasts and its contribution to cardiac fibrosis following myocardial infarction. The research employs advanced...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant of $556,121 on January 15, 2026, under the Aging Research program (CFDA 93.866) to conduct research on transgenerational adaptation of longevity changes in response to repeated environmental stresses. The research project, which extends through December 31, 2030, will investigate how repeated exposures to environmental stresses across successive generations trigger...
- Federal Project Grant Award Summary The University of California, San Diego received a $437,375 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through August 31, 2027. The award funds biomedical research investigating NEK7 (NIMA-related kinase-7) as a potential suppressor of inflammation in aging hearts through regulation of RNA-binding proteins. The research addresses the critical connection between...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Indiana University Indianapolis $3,126,515 on August 15, 2025, under the Aging Research program (CFDA 93.866) to support research investigating a novel inter-tissue L-BAIBA/FGF23 (L-beta-aminoisobutyric acid/fibroblast growth factor 23) signaling axis as a therapeutic target for enhancing musculoskeletal remodeling in aging populations. The research project, with a completion date of May 31, 2029, will generate...
The National Institute on Aging (NIA) awarded Iowa State University of Science and Technology a Project Grant of $523,313 on June 1, 2026, to support research on non-autonomous regulation of cardiac aging through the Aging Research program (CFDA 93.866). The research project, which extends through March 31, 2031, investigates the role of ether phospholipids, particularly plasmalogens, in kidney-heart communication and age-related cardiac decline. The principal deliverables include scientific research and discovery addressing four specific aims: determining the mechanisms underlying age-associated decreases in kidney plasmalogen biosynthesis; characterizing plasmalogen transport pathways from the kidney to the heart; and evaluating how kidney-derived plasmalogens regulate cardiac contractile performance. This multidisciplinary investigation will generate biomedical knowledge regarding the aging process and potential therapeutic targets for age-related cardiovascular disease, consistent with NIA's mission to support research directed toward understanding aging and age-related conditions. The research will be conducted at Iowa State University's facilities in Ames, Iowa, leveraging the institution's established expertise in biomedical research and its demonstrated capacity as a federal research partner. As a comprehensive land-grant research institution with substantial experience in NIH-funded research projects, Iowa State University will deliver peer-reviewed scientific findings, experimental data, and research publications that advance understanding of cardiac aging mechanisms and inter-tissue communication pathways relevant to aging biology and cardiovascular health.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $523.3k | 5/26/26 |