Project Grant R01HL181428
- This Project Grant award of $684,937.00, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of the junctophilin-1 (JP1) protein in cardiac function and heart failure. The research project is being conducted at The University of Iowa, a prominent public research university with extensive experience in federal contracting and grant work. The project aims to dissect the function of JP1...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to the University of Utah provides $745,663 to investigate the role of the IRE1 protein in regulating cardiac fibrosis, a key mechanism underlying heart failure. The research aims to elucidate how the unfolded protein response (UPR) in cardiac fibroblasts affects their activation and production of extracellular matrix proteins during the progression of both reduced and...
- The federal Project Grant award of $726,452 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to model intra- and inter-cellular networks involved in TRPC6-dependent cardiac fibrosis. The award aims to leverage computational methods and multi-scale experiments to better understand how TRPC6 signaling drives myofibroblast transformation and fibrosis in response to cardiac and dermal wounds. The research will be conducted by the...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $811,885 in funding to the J. David Gladstone Institutes in California to conduct research on epigenomic mechanisms of cardiac fibrosis and heart failure. The project aims to investigate the role of the MEOX1 gene as a key transcriptional regulator of fibroblast activation, fibrosis, and heart failure pathogenesis. The research leverages novel genetic mouse...
- This Project Grant award of $248,431.00, granted by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), supports research at The Johns Hopkins University to investigate the role of microenvironment mechanics in regulating cardiac myofibroblast plasticity. The research aims to leverage human induced pluripotent stem cell-derived cardiac fibroblasts, engineered biomaterials, and single-cell multiomics platforms to elucidate...
- This Project Grant award, valued at $1,088,500.00, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The University of Iowa. The award supports three independent research projects related to genetic and molecular mechanisms of heart disease. Project #1 aims to define microRNA (miR) targeting events and their biological relevance in the heart, as well as understand the clinical significance of single nucleotide polymorphisms (SNPs)...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $159,512.00 to The Leland Stanford Junior University to conduct research on ameliorating cardiac fibrosis using human cardiac organoid models. The project aims to discover treatments for cardiac fibrosis, a hallmark of dilated cardiomyopathy, by validating potential compounds identified in a prior high-throughput screen using complex 3D cardiac organoids...
- The University of Iowa was awarded a $612,186 Project Grant by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to conduct research on the role of the lysosome in heart failure with preserved ejection fraction (HFPEF). The project aims to determine the pathophysiological impact of cardiac lysosomal dysfunction in HFPEF, which accounts for half of heart failure hospitalizations in the U.S. The research will investigate how the lysosomal protein GILT...
- This federal Project Grant award of $740,037, funded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research on the regulation of angiogenesis (blood vessel formation) by cardiac fibroblasts following myocardial infarction. The key objectives are to investigate the temporal and spatial expression of pro- and anti-angiogenic factors secreted by cardiac fibroblasts to support cardiac repair and increase vascular...
- This Project Grant award, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research on how tissue elasticity and viscosity modulate the signaling between macrophages and fibroblasts in cardiac fibrosis. The $231,552 award, granted to the University of California, San Diego, will fund research to investigate the effects of mechanical stimuli on macrophage-fibroblast interactions and explore the role of a changing mechanical...
The federal Project Grant award of $651,009 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Iowa to investigate the role of the protein junctophilin-2 (JP2) in regulating calcium signaling in cardiac fibroblasts and its impact on cardiac fibrosis. The project aims to employ advanced molecular, physiological, and biochemical techniques, along with innovative mouse models, to elucidate the specific mechanisms by which JP2 influences cardiac fibroblast responses to ischemic injury and contributes to aberrant fibrotic remodeling. The award period extends from Sep 12, 2025 to May 31, 2029, with the goal of providing novel knowledge on JP2's physiological and pathophysiological functions in the context of cardiac fibrosis and informing potential therapeutic strategies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $651.0k | 9/12/25 |