Project Grant R21AI193780
- The University of Iowa was awarded a $1,354,009 Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The grant, which runs from September 1, 2024 to August 31, 2027, aims to develop clinically deliverable RNA strategies for radiation protection. Specifically, the project will leverage the protective qualities of extremophile proteins and new delivery methods to reduce the impact of radiation-induced injuries...
- This Project Grant award of $158,500 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports the development of a novel non-pharmacological strategy to mitigate radiation-induced cardiotoxicity. Specifically, the research team at the Trustees of Indiana University Indianapolis will investigate the use of a small subcutaneous incision, termed "protective wounding," to enhance hematopoietic recovery and preserve cardiac function in mice...
- This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $155,000 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to investigate the mitochondrial serine/threonine phosphatase PGAM5 as a potential target for mitigating gastrointestinal acute radiation syndrome (GI-ARS). The research aims to examine the role of PGAM5 in radiation-induced oxidative stress and modulation of Wnt/β-catenin...
- The U.S. Department of Health and Human Services National Institutes of Health (NIH) awarded a $156,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Medical College of Wisconsin, Inc. The overall objective of this 2-year project, from August 1, 2025 to July 31, 2027, is to develop a panel of biomarkers that can discriminate between exposure of upper- and lower-body organs to radiation and predict health outcomes. The research aims to identify organ-specific...
- This Project Grant award of $153,000.00, provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), focuses on investigating potential radiomitigating strategies for gastrointestinal acute radiation syndrome (GI-ARS). The research project has two novel approaches: 1) Evaluating the mitigating effects of dietary methionine restriction on GI-ARS following radiation exposure, and 2) Exploring a second approach outlined in Aim 2 (details not...
- This Project Grant award, valued at $1,088,500.00, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The University of Iowa. The award supports three independent research projects related to genetic and molecular mechanisms of heart disease. Project #1 aims to define microRNA (miR) targeting events and their biological relevance in the heart, as well as understand the clinical significance of single nucleotide polymorphisms (SNPs)...
- This $153,169 federal Project Grant award from the National Institutes of Health (CFDA 93.310 Trans-NIH Research Support program) to The Ohio State University aims to develop a rapid, non-invasive method for assessing radiation exposure using Raman spectroscopy and artificial intelligence. The project will collect and analyze hair samples from mice exposed to controlled radiation doses to develop models for detecting exposure greater than 2 Grays and differentiating higher doses above 5 Grays....
- The National Institutes of Health (NIH) awarded a $156,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to Georgetown University on August 11, 2025. The project, titled "Development of a Multiomic Biodosimetry Panel for Use During Sepsis and Antibiotic Treatment", aims to develop a novel panel of metabolomic and gene expression biomarkers to rapidly screen and provide accurate dose reconstruction for individuals exposed to ionizing radiation. This panel will...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $760,982 to The University of Texas MD Anderson Cancer Center to investigate the role of the GFPT2 enzyme in radiation-induced cardiovascular disease. The project aims to determine the fundamental mechanisms contributing to radiation-induced cardiovascular disease, identify high-risk patients, and establish new treatment approaches. Key objectives...
- This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) totaling $157,000.00 is supporting research to develop a new class of radiation mitigating agents as medical countermeasures for hematopoietic acute radiation syndrome (H-ARS). The principal investigators from the collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences will examine the mitigating effects of the small molecule...
This federal Project Grant award of $155,500 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) will support research at the University of Iowa to investigate the role of nitro-oxidative signaling and mitochondrial metabolism in mitigating age-associated, radiation-induced cardiopulmonary damage. The research will utilize genetically modified mice and an upper body irradiation model to elucidate the impact of nitric oxide synthase 1 (NOS1) disruption and assess the efficacy of a superoxide dismutase mimetic (rucosopasem) in ameliorating these age-related effects. The goal is to better understand how age-associated disruptions in mitochondrial complex assembly contribute to oxidative stress and subsequent cardiopulmonary damage following radiation exposure. This 2-year project aims to advance scientific knowledge in this area and develop potential therapeutic interventions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $155.5k | 7/31/25 |