Project Grant R21AG086743
- This federal Project Grant award of $551,863 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research on how prostaglandin E2 (PGE2) regulates airway epithelial cells to balance liquid absorption and secretion. The research aims to establish new regulatory mechanisms controlling airway surface liquid volume, with the goal of identifying novel therapeutic targets for pulmonary diseases. The project is conducted by researchers at the...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $639,740.00 to investigate the role of the CD38 enzyme in the development of chronic lung conditions following viral infections like COVID-19. The research aims to explore how targeting CD38 on CD8 tissue resident memory (TRM) cells could mitigate age-associated lung fibrosis after viral pneumonia. The award, effective December 15, 2024 through November 30, 2029, will support the lead researcher...
- The federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to understand the mechanisms linking the cystic fibrosis transmembrane conductance regulator (CFTR) gene to dysregulated barrier function, insulin receptor function, and glucose transport in the lungs of cystic fibrosis (CF) patients. The $730,494 award to Emory University, with a sub-award to Vanderbilt University Medical Center, aims to investigate...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $422,075 to The University of Iowa to develop an electromagnetic-actuated, dynamic cell culture method for airway epithelial cells. The project aims to prototype a novel "Magniwell-12" system that integrates a porous PDMS membrane, membrane holder, magnetic actuator, and peripheral heat dissipation/control circuits. This will enable dynamic stretch-relax...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $431,750 aims to isolate and characterize peptide ligands targeting vascular endothelial cells (VECs) in young versus aged mice in vivo and senescent versus non-senescent murine VECs in vitro. The primary objectives are to enhance the understanding of molecular mechanisms and age-related pathologies associated with vascular dysfunction during aging. The project seeks to...
- This Project Grant award, valued at $1,088,500.00, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The University of Iowa. The award supports three independent research projects related to genetic and molecular mechanisms of heart disease. Project #1 aims to define microRNA (miR) targeting events and their biological relevance in the heart, as well as understand the clinical significance of single nucleotide polymorphisms (SNPs)...
- This federal Project Grant award of $752,589.00 from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research aims to study the relationship between pathologies in peripheral nerves and the brain, as well as the impact of brainstem pathology and synapse loss, in individuals who died with Alzheimer's disease or related dementias. The award to the University of Iowa, a major public research university, will fund a 5-year research project starting on January 1, 2025 to address the...
- This Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866), aims to elucidate the role of reverse electron transport (RET) in lung aging and idiopathic pulmonary fibrosis (IPF). The $460,283 award to the University of California, San Francisco (UCSF) supports a 2-year investigation focused on two key objectives: 1) conducting a detailed gene expression analysis to understand RET's influence on pro-fibrotic gene...
- This federal Project Grant award of $286,000 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), aims to investigate how age-related lipid dysregulation in brain endothelial cells contributes to cognitive impairment. The research will assess the effects of lipid droplet accumulation on endothelial structure and function, and evaluate how this impacts microvascular aging and cognitive decline. The award was made to the University of Oklahoma Health Sciences...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides funding of $374,576 from September 5, 2025 to August 31, 2027 to Louisiana State University Health Sciences Center New Orleans. The grant supports research to investigate the role of neutrophils, a type of immune cell, in the pathogenesis of cystic fibrosis (CF). The research aims to elucidate how CFTR, the gene mutated in CF, impacts neutrophil function and the...
The University of Iowa received a $427,625 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to study the role of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein in regulating endothelial function and vascular tone, particularly as it relates to aging in cystic fibrosis patients. The research aims to evaluate how aging-induced endothelial dysfunction is accelerated by endothelial deletion of CFTR, and to examine the mechanism by which CFTR regulates endothelial nitric oxide synthase (eNOS) production. This 2-year grant, awarded on Sep 18, 2025, will utilize a novel mouse model to investigate the CFTR-eNOS regulation as a potential mechanism for CFTR-dependent control of endothelial function.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 9/16/25 |