Project Grant R01AG094714
- The National Institute on Aging at the Department of Health and Human Services awarded Mayo Clinic $878,516 in project grant funding on June 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a six-week clinical study examining high-resistance inspiratory muscle strength training as an intervention to reduce sympathetic nerve activity and improve sleep in postmenopausal women experiencing hot flashes. The research addresses vasomotor symptoms associated with menopause, which...
- The National Institute on Aging awarded the University of Florida Division of Sponsored Research $618,412 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms of menopause-induced coronary microvascular disease and develop novel therapies. The research project, titled "Menopause Transition and Coronary Microvascular Disease," examines how hormonal imbalance during menopause increases cardiovascular disease risk in women,...
- The National Institute on Aging awarded the University of Delaware $1,303,632 on February 1, 2026, under the Aging Research program (CFDA 93.866) to examine sympathetic nervous system activation during the menopausal transition and its contribution to cardiovascular disease risk in women. The research addresses a gap in understanding physiological changes in cardiovascular function as follicle-stimulating hormone increases and estradiol declines across premenopausal, early perimenopausal, late...
- The National Institute on Aging awarded New York University School of Medicine $3,557,115 on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate the neurobiological mechanisms linking menopause and cognitive decline in women. The recipient will conduct a longitudinal study mapping neurobiological changes during the menopause transition in a cohort of 120 pre- and perimenopausal women aged 40–48 using state-of-the-art neuroimaging, plasma proteomics, and clinical...
- The National Institute on Aging awarded Mayo Clinic $678,684 under the Aging Research program (CFDA 93.866) on September 1, 2026, to investigate the neural mechanisms of respiratory dysfunction in older age. The research explores how impaired autophagy in phrenic motor neurons contributes to selective loss of higher-force motor units with advancing age, and whether restoring autophagy prevents this loss. The project employs loss-of-function and gain-of-function experiments using conditional...
- The National Institute on Aging, a component of the Department of Health and Human Services National Institutes of Health, awarded $433,125 to the University of Missouri System on June 1, 2026, under the Aging Research program (CFDA 93.866) to investigate beta-3 adrenergic receptor signaling and cardiovascular function in aging women. The research addresses loss of vascular beta-adrenergic receptor protection in postmenopausal women and proposes a personalized therapeutic approach using...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The General Hospital Corporation (Massachusetts General Hospital) $680,011 on August 1, 2026, under the Aging Research program (CFDA 93.866, Project Grant R01AG094740). The award funds research into the molecular mechanisms underlying tendon pathology in a murine model of menopause. The project investigates why postmenopausal women experience accelerated tendon injury and disease compared with similarly...
- The National Institute on Aging awarded Mayo Clinic $729,906 on September 3, 2026, under the Aging Research program (CFDA 93.866) to investigate the neurobiological substrates of falls in cognitively unimpaired older adults. The research uses dual-task paradigms that simultaneously engage motor and cognitive brain systems to characterize subclinical gait impairment patterns among cognitively unimpaired individuals who experience falls. The study assesses how gait impairment relates to...
- The National Institute on Aging awarded the University of Washington $684,271 under the Aging Research program (CFDA 93.866) on September 1, 2026. The award funds research examining the relationship between hypertensive pregnancy disorders and cardiovascular risk during the menopause transition, using a life-course approach. The study leverages data from the Study of Women's Health Across the Nation (SWAN), a cohort of 3,302 premenopausal or early perimenopausal participants aged 42 to 52 at...
- Federal Grant Award Summary Mayo Clinic received a $3.38 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded September 15, 2025, with completion targeted for September 14, 2029. The grant supports research to advance women-specific care in Alzheimer's disease and other dementias through systematic analysis of electronic health records (EHRs). The project addresses a critical gap in precision medicine by examining women-specific health...
The National Institute on Aging awarded Mayo Clinic $678,987 on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate the impact of menopause on blood pressure regulation during exercise. The research tests whether locomotor muscle afferent feedback and respiratory muscle work contribute to exaggerated blood pressure responses and impaired leg blood flow in post-menopausal women during submaximal exercise. The project has two specific aims: to determine if locomotor muscle afferent feedback drives augmented blood pressure and impaired locomotor muscle blood flow responses during exercise in post-menopausal women, and to establish whether respiratory muscle work contributes to augmented blood pressure and abnormal central and peripheral hemodynamic responses during exercise in the same population. The underlying premise is that post-menopausal women display higher respiratory muscle work during exercise compared to pre-menopausal women, and that this physiological change, combined with altered muscle afferent feedback, predisposes them to heightened cardiovascular risk during physical activity. Performance occurs in Minnesota and runs through April 30, 2031. The award is classified as a Project Grant under the Aging Research program, which supports biomedical and behavioral research directed toward understanding aging and preventing Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $679.0k | 8/4/26 |