Project Grant R01AG094712
- The National Institute on Aging awarded the University of Delaware $1,303,632 on February 1, 2026, under the Aging Research program (CFDA 93.866) to examine sympathetic nervous system activation during the menopausal transition and its contribution to cardiovascular disease risk in women. The research addresses a gap in understanding physiological changes in cardiovascular function as follicle-stimulating hormone increases and estradiol declines across premenopausal, early perimenopausal, late...
- The National Institute on Aging awarded Mayo Clinic $678,987 on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate the impact of menopause on blood pressure regulation during exercise. The research tests whether locomotor muscle afferent feedback and respiratory muscle work contribute to exaggerated blood pressure responses and impaired leg blood flow in post-menopausal women during submaximal exercise. The project has two specific aims: to determine if locomotor...
- The National Institute on Aging awarded New York University School of Medicine $3,557,115 on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate the neurobiological mechanisms linking menopause and cognitive decline in women. The recipient will conduct a longitudinal study mapping neurobiological changes during the menopause transition in a cohort of 120 pre- and perimenopausal women aged 40–48 using state-of-the-art neuroimaging, plasma proteomics, and clinical...
- The National Institute on Aging awarded Rosalind Franklin University of Medicine & Science $696,253 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how hormonal fluctuations during perimenopause alter hippocampal neural circuits and accelerate Alzheimer's disease pathology in female mice. The recipient will use 4-vinylcyclohexene diepoxide (VCD) to chemically induce ovarian failure in AppNLGF knock-in AD model mice, mimicking human perimenopause...
- The National Institute on Aging awarded $214,140 to the University of California, Los Angeles on March 18, 2026, under the Aging Research program (CFDA 93.866) to conduct research on estrogenic signaling mechanisms that regulate metabolic response to energy deficit. The research aims to understand how circulating estrogens reduce fasting-induced torpor usage in mice, thereby maintaining high energy expenditure despite dangerous energy deficits—findings relevant to metabolic changes during...
- The National Institute on Aging awarded The Regents Of The University Of Colorado (doing business as University Of Colorado-Denver) $429,000 on January 1, 2026, under the Aging Research program (CFDA 93.866) to define the role of decreased estradiol in modulating crotonylation of myofilament proteins in aged female hearts. The research addresses diastolic dysfunction in postmenopausal women, investigating biochemical mechanisms underlying estradiol-mediated cardioprotection. The project examines...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The General Hospital Corporation (Massachusetts General Hospital) $680,011 on August 1, 2026, under the Aging Research program (CFDA 93.866, Project Grant R01AG094740). The award funds research into the molecular mechanisms underlying tendon pathology in a murine model of menopause. The project investigates why postmenopausal women experience accelerated tendon injury and disease compared with similarly...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $552,154 on February 1, 2026, under the Aging Research program (CFDA 93.866) to characterize hormone therapy use patterns in women with premature or early menopause, identify patient and physician factors associated with therapy initiation and continuation, and develop a dynamic risk prediction model to identify women at high risk for underuse. The project addresses an evidence gap: up to 3.1...
- The National Institute on Aging awarded The Washington University $326,550 on June 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the neural circuit basis of age-related changes in female sexual behavior during reproductive aging. The project, led through Washington University's Office of Sponsored Research Services in St. Louis, Missouri, will define how hormonal decline during menopause disrupts hormone-sensitive neural circuits and impairs female sexual behavior....
- The National Institute on Aging at the Department of Health and Human Services awarded Mayo Clinic $878,516 in project grant funding on June 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a six-week clinical study examining high-resistance inspiratory muscle strength training as an intervention to reduce sympathetic nerve activity and improve sleep in postmenopausal women experiencing hot flashes. The research addresses vasomotor symptoms associated with menopause, which...
The National Institute on Aging awarded the University of Florida Division of Sponsored Research $618,412 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms of menopause-induced coronary microvascular disease and develop novel therapies. The research project, titled "Menopause Transition and Coronary Microvascular Disease," examines how hormonal imbalance during menopause increases cardiovascular disease risk in women, specifically focusing on coronary microvascular disease, a type of non-obstructive coronary artery disease characterized by attenuated vasodilatation and vascular remodeling. The study uses inducible menopause mouse models generated through VCD injection and ovariectomized mice to investigate coronary microvascular function, measured by coronary flow velocity reserve. Preliminary data demonstrate decreased microvascular function in perimenopausal and postmenopausal mice, downregulation of genes related to endothelium-dependent relaxation, and improved coronary flow velocity reserve following chronic administration of a TRPV4 agonist. The research ultimately aims to identify mechanisms underlying menopause-induced coronary microvascular disease, addressing a gap in treatment options where CMD patients are currently managed with medications developed for obstructive coronary artery disease with limited effectiveness. Performance occurs in Jupiter, Florida. The award period runs from September 1, 2026, through May 31, 2031. The Aging Research program supports biomedical, social, and behavioral research directed toward understanding the aging process and age-related diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $618.4k | 8/31/26 |