Project Grant R01AG079924

Award Date 9/15/24
Completion Date 3/31/29
Dollars Obligated $2.5M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Tucson, AZ 85724, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $425,958 to the University of Arizona to study the role of the hormone glucagon in mediating the health and longevity benefits of calorie restriction in humans. The key objectives are to: 1) Measure serum levels of glucagon, glucagon-like peptide-1 (GLP-1), and fibroblast growth factor 21 (FGF21) in participants of the CALERIE calorie restriction trial at baseline, 12 months, and 24 months...
This $659,916 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to test the ability of diets with reduced levels of specific amino acids (isoleucine, valine, or histidine) to reverse diet-induced obesity and insulin resistance. The primary objectives are to determine the optimal degree of amino acid restriction to promote metabolic health in animal models, and to evaluate the efficacy of an optimized amino acid-restricted diet in...
The National Institute on Aging (NIA) awarded a $1,980,133 Project Grant (CFDA 93.866 - Aging Research) to The University of Texas Health Science Center at San Antonio (UTHSCSA) to explore the impact of leptin modulation on healthspan and lifespan. The research project aims to assess whether aging-associated hyperleptinemia accelerates cellular senescence and impairs healthspan and lifespan, evaluate the effects of reducing leptin on cellular senescence, healthspan, and lifespan, and elucidate...
The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a 5-year, $753,728 Project Grant (R01AG085793) to the University of Alabama at Birmingham (UAB) to investigate the role of ceramide signaling in regulating healthspan and lifespan in mouse models. The study aims to determine the association between growth hormone deficiency, altered lipid profiles, and longevity, with a focus on the implications of ceramides in aging-related processes...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to define the role of astrocytic and neuronal melanocortin 4 receptor (MC4R) populations in age-related hippocampal inflammation and cognitive decline. The $393,250 award, effective from June 1, 2025 to May 31, 2027, will support research conducted by the University of Oklahoma Health Sciences Center to investigate the cell-type specific effects of MC4R activation on neuroinflammation and...
This Project Grant award of $395,796 from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research at Brown University to develop genetic, pharmacological, and dietary interventions that delay the onset and progression of age-related diseases. The key objectives are to: 1) Investigate the interconnectedness and hierarchical structure of the hallmarks of aging, such as loss of genomic integrity, activation of retrotransposons, and accumulation of lipid droplets; 2)...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of aging. The project aims to evaluate how a population of mouse T cells can be iteratively boosted and passaged among young mice for over 11 years, exceeding the normal mouse lifespan, while retaining functional competence and proliferative potential. The research will investigate factors such as...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support research by Tufts University School of Medicine to develop metabolomics clocks as a tool to explore the mechanisms of aging. The total funding amount is $592,507 and the award period runs from Sep 30, 2024 to Jun 30, 2029. The key objectives of the project are to: 1) develop sex- and tissue-specific metabolome clocks in the Drosophila model system that can...
This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
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This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $2,496,057.49 to the University of Arizona to investigate the role of hepatic glucagon receptor signaling in healthspan and aging. The research aims to study the impact of genetic and pharmacological manipulation of glucagon receptor signaling on normal aging, obesity-accelerated aging, and the effects of calorie restriction. This work seeks to identify glucagon receptor signaling as a potential therapeutic target to extend healthspan and lifespan, given the limitations of targeting insulin signaling. The award period runs from September 15, 2024 to March 31, 2029.

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