The National Institute on Aging (NIA) awarded a $1,532,172.66 Project Grant (CFDA 93.866 - Aging Research) to the University of Arizona to investigate the role of hepatic glucagon receptor signaling in healthspan and aging. The research aims to study the impacts of genetic and pharmacological manipulation of glucagon receptor signaling on normal aging, obesity-accelerated aging, and the effects of calorie restriction. This work builds on the researchers' previous findings demonstrating that...
This $653,189 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research at The University of Texas Southwestern Medical Center to investigate the impact of caloric restriction and circadian rhythms on healthspan and lifespan. The grant aims to determine whether time-restricted feeding without caloric restriction can extend lifespan, whether enhancing clock gene expression can improve health and lifespan, and whether the cytokine...
This $467,416 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) will fund a study by Tufts University School of Medicine to examine the effects of calorie restriction (CR) on mitochondrial DNA (mtDNA) heteroplasmy and its association with biological aging and cardiometabolic health. The overarching goal is to understand whether CR attenuates the accumulation of mtDNA heteroplasmic mutations, which have been implicated in...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to test the ability of diets with reduced levels of isoleucine, valine, or histidine to reverse diet-induced obesity and insulin resistance in order to promote healthy aging. The $659,916 award will support research to determine the optimal degree of restriction of these three amino acids that promotes metabolic health in diet-induced obese mice, as well as test an optimized amino acid-restricted...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $429,000 to the Regents of the University of Michigan to conduct research on non-canonical mechanisms and unconventional approaches to activate AMP-activated protein kinase (AMPK) and improve glucose uptake in the skeletal muscle of older rats. The key objectives are to: 1) Determine the effects of caloric restriction on AMPK regulators and activation in skeletal muscle subcellular...
This federal Cooperative Agreement award, issued by the National Institute on Aging (CFDA 93.866 - Aging Research), provides $1,361,299.00 in funding to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to conduct research on the role of endogenous steroid hormones, particularly glucocorticoids, in mediating interorgan communication with the musculoskeletal system during aging. The project aims to leverage novel mouse models to investigate how...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $652,286 Project Grant to Northeastern University. The grant, titled "Genome-Wide CRISPR Activation: A Novel Strategy for Identifying Anti-Aging Targets," aims to systematically identify genes that modulate lifespan and health in the model organism C. elegans using advanced CRISPR activation technology. The research team, with expertise in aging genetics and high-throughput...
The National Institute on Aging (NIA) awarded a 5-year, $753,728 Project Grant (CFDA 93.866 - Aging Research) to the University of Alabama at Birmingham (UAB) to investigate the role of ceramide signaling in regulating healthspan and lifespan in mouse models. The study aims to determine how genetic and pharmacological interventions that lower ceramide levels impact aging-associated pathways, including insulin resistance, mitochondrial dysfunction, inflammation, and cellular senescence. The...
This $592,507 project grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Tufts University School of Medicine aims to develop metabolomic clocks as a tool to explore mechanisms of aging. The key products and services to be delivered include: Developing sex- and tissue-specific metabolome clocks in the Drosophila model system to serve as biomarkers of aging with high translational potential. Determining the significance of metabolome clock components as mechanisms...
The National Institute on Aging (CFDA 93.866 Aging Research) awarded a $1,339,916 Project Grant to The University of Texas Health Science Center at San Antonio (UTHSCSA) to explore the impact of leptin modulation on healthspan and lifespan. The key objectives of this 5-year project are to: Test whether aging-associated hyperleptinemia accelerates cellular senescence and impairs healthspan and lifespan. Assess the effects of reducing leptin on cellular senescence, healthspan, and lifespan....
This Project Grant award, provided by the National Institute on Aging under CFDA Program 93.866 (Aging Research), aims to study the role of the hormone glucagon in the mechanisms by which calorie restriction (CR) improves metabolic health and slows aging in humans. The $425,958 award to the University of Arizona will fund two main research activities over a 2-year period ending in October 2026:
Measuring serum concentrations of glucagon, glucagon-like peptide-1 (GLP-1), and fibroblast growth factor 21 (FGF21) in participants of the CALERIE trial, a long-term CR study, to assess changes in glucagon sensitivity under CR conditions.
Evaluating the relationships between glucagon, GLP-1, FGF21, and various biomarkers of lipid, glucose, and energy homeostasis in the CALERIE trial participants to further elucidate the role of glucagon in the beneficial metabolic effects of CR.
The study aims to provide key insights into the essential functions of glucagon signaling in CR-induced improvements in healthspan and lifespan, which could inform the development of novel therapies targeting the glucagon receptor for promoting healthy aging.