Project Grant R01AG093699
- The National Institute on Aging awarded the Regents of the University of Michigan $284,108 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how mechanical changes in the aging brain affect microglial function and Alzheimer's disease progression. The project explores the relationship between age-related mechanical alterations in brain tissue—specifically decreased stiffness and increased viscoelasticity resulting from reduced tissue connectivity—and microglial...
- The National Institute on Aging awarded the Regents of the University of Michigan $116,079 on September 1, 2026, under the Aging Research program (CFDA 93.866) to assess how multilevel life course socioeconomic conditions relate to disparities in Alzheimer's disease and related dementias. The project examines socioeconomic trajectories at both individual and neighborhood levels in relation to cognitive decline, dementia incidence, and brain health indicators including structural magnetic...
- The National Institute on Aging awarded the Regents of the University of Michigan $758,442 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and test two pragmatic interventions aimed at increasing brain donation among older adults at risk for Alzheimer's disease and related dementias. The project, "The Brain Gifting Counseling Program: A Novel Peer-Professional Intervention to Enhance Brain Donation Among Older Adults at Risk for Alzheimer's Disease and...
- The National Institute on Aging awarded the Regents of the University of Michigan $654,999 on September 1, 2026, under the Aging Research program (CFDA 93.866) to assess cognitive functioning in the National Monitoring the Future (MTF) Panel Study. The award funds the addition of web-based cognitive measures to the MTF Panel, a nationally representative longitudinal study of high school seniors followed since 1975. The cognitive measures—assessing memory, numeracy, executive functioning, word...
- The National Institute on Aging awarded the Regents of the University of Michigan $844,638 on September 15, 2025, under the Aging Research program (CFDA 93.866) to implement and test a pharmacist-led care transition program for rural older adults with dementia. The project adapts the Region VII Area Agency on Aging Community Care Transition Initiative (CCTI) for older adults with Alzheimer's disease and related dementias (ADRD) and their care partners. Rural older adults with ADRD commonly...
- The National Institute on Aging awarded Regents of the University of Michigan $131,760 on August 1, 2026, under the Aging Research program (CFDA 93.866) to support research on hippocampal-prefrontal interactions underlying trace memory in aging and a rodent model of Alzheimer's disease. The investigator will perform simultaneous electrophysiological recordings in the hippocampus and calcium imaging recordings in the prefrontal cortex of freely moving rats as they perform a trace conditioning...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $298,419 to the Regents of the University of Michigan on February 1, 2026, under the Aging Research program (CFDA 93.866, Assistance Listing Project Grant R01AG097771). The recipient will develop advanced statistical and computational methods for analyzing immune cell data to enhance understanding of the immune system's role in aging and age-related diseases. The project addresses analytical...
- The National Institute on Aging awarded Dabble Health, Inc. $999,372 on September 20, 2025, under the Aging Research program (CFDA 93.866) to develop and validate Momento, a smartphone application that uses AI-enhanced personal photo activities to detect early signs of cognitive decline in older adults. Phase I work includes usability testing with 200 older adults to ensure sustained engagement with the app, and validation of the system's cognitive assessment accuracy against gold-standard...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the Regents of the University of Michigan $779,211 on September 2, 2026, under the Aging Research program (CFDA 93.866) to investigate the health, functional, and financial impacts of Medicaid disenrollment on adults ages 50-64 in Michigan. The research team will conduct a longitudinal two-wave survey of Michigan Medicaid enrollees ages 50-64 to evaluate how disenrollment affects insurance coverage,...
- The National Institute on Aging awarded the University of Alabama at Birmingham $5,057,416 on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine the impact of undiagnosed dementia on healthcare utilization across geographic regions. The recipient will augment Medicare claims data with cognitive assessment data from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a longitudinal cohort of 30,239 participants from 1,833 counties across the...
The National Institute on Aging awarded the Regents of the University of Michigan $935,722 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a randomized controlled trial of MOVE2JOY, an mHealth intervention designed to promote physical activity in middle-aged and older adults to reduce Alzheimer's disease and related dementia risk. MOVE2JOY combines two innovations: reinforcement learning algorithms that personalize intervention delivery to promote long-term engagement and effectiveness, and direct addressing of affective barriers—negative emotions, feelings, and judgments about physical activity that aging adults develop due to chronic conditions. The intervention targets physical activity as a key dementia prevention strategy, leveraging mobile apps and wearables to deliver scalable, sustained support beyond the typical 6–12 month effectiveness decline seen in current mHealth physical activity programs. Work is performed at the University of Michigan in Ann Arbor, Michigan, with a period of performance from September 1, 2026, through August 31, 2031. This award is structured as a Project Grant under the National Institute on Aging's mission to support biomedical and behavioral research and training directed toward preventing and treating Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $935.7k | 9/1/26 |