This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,041,438 to develop new computational tools and biomarkers for Alzheimer's disease. The University of Miami will aggregate and analyze DNA methylation datasets to identify age-associated epigenetic changes related to aging and Alzheimer's progression. Researchers will create a searchable web interface to disseminate findings on the role of DNA...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai provides $842,114 to systematically investigate the molecular mechanisms of brain senescence in different molecular subtypes of Alzheimer's disease (AD). The project aims to identify and characterize senescent cells in major subtypes of AD using advanced single-cell multi-omics and spatial transcriptomics techniques. This comprehensive research initiative is...
This $125,896 Project Grant, awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports a research project led by The Washington University in St. Louis. The project aims to utilize state-of-the-art single-nuclei multi-omic functional genomic analyses of healthy and Alzheimer's disease (AD) human brain tissue, as well as transgenic AD mouse models, to perform deep molecular characterization of AD risk and resilience pathways across genetic, epigenomic,...
This $766,467 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to the Georgia State University Research Foundation Inc. The funding supports the development of flexible multivariate models that can jointly analyze multi-scale neuroimaging and genomic data to better understand Alzheimer's disease and related dementias (ADRD). The proposed models aim to address key limitations of existing multivariate data fusion...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $619,681 to The Leland Stanford Junior University will support the development of "Combo-Seq/Tag", a toolkit combining gene editing and protein tagging technologies. The goal is to efficiently perturb Alzheimer's disease (AD) risk genes and conduct multi-omics analyses in human stem cell and in vivo mouse models. The award will yield innovative gene editing vectors...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $551,986.00 to The Jackson Laboratory to develop an explainable unified AI strategy for efficient and robust integrative analysis of multi-omics data from heterogeneous longevity studies. The goal is to identify protective genetic variants associated with exceptional human longevity, which can inform therapeutic interventions to improve human health. The 2-year project aims to: 1) create...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,281,385 to the University of California, San Diego (UCSD) to examine the role of specific phenotypes, such as sex/gender, APOE4 status, and polygenic hazard scores, on response to drug or lifestyle interventions in existing Alzheimer's disease clinical trial datasets. The project aims to leverage 30 years of harmonized data from 14,602 participants across multiple clinical trials to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $372,690 to the University of California, Berkeley to conduct research aimed at understanding the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The key objectives are to: 1) Develop new statistical methods for uncovering heterogeneous causal relationships among amyloid-beta, tau accumulation, and cognition across diverse AD datasets; 2) Apply these methods to reveal optimal...
This $301,417 federal Project Grant award, provided by the National Institute on Aging under CFDA 93.866 Aging Research, aims to develop innovative analytical methods and software tools for integrating and synthesizing data from Alzheimer's disease and related dementias (AD/ADRD) research studies. The key objectives are to: 1) Create new approaches for modeling and addressing inconsistencies in the evidence from network meta-analyses of AD/ADRD interventions, and 2) Develop novel network...
This National Institute on Aging (NIA) Project Grant award under CFDA Program 93.866 "Aging Research" provides $254,250 to New York University (NYU) School of Medicine to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The project aims to create a brain microstructure age framework by generating brain charts of quantitative dMRI and mesoscopic MRI (mesoMRI) markers across the lifespan. It will evaluate the effects of...
This Project Grant award, valued at $802,034 and funded by the National Institute on Aging's Aging Research program (CFDA 93.866), aims to develop a comprehensive "multimodal, multiscale and multistage systems biology (M3SB) infrastructure" to advance precision medicine for Alzheimer's disease (AD) and longevity research.
The key objectives are to: 1) conduct multi-omics analyses to identify bioage-modifying targets and repurposable medicines for AD and related dementias; 2) build inflammatory aging (iAge) and phenoage clocks using longitudinal biomarker, neuroimaging, and electronic health record data to understand disease progression; and 3) validate candidate iAge- and phenoage-derived treatments using patient-derived neurons, brain organoids, and animal models. This comprehensive project aims to create flexible, accurate computational models and toolkits to better categorize disease complexity and develop interpretable insights for Alzheimer's precision medicine.