Project Grant R01AG091918

Award Date 12/1/24
Completion Date 11/30/29
Dollars Obligated $661K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Waltham, MA 02453, USA
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This National Institute on Aging (NIA) Project Grant award under the Aging Research Federal Grant Program (CFDA 93.866) provides $449,625 to Trustees of Boston University to explore the role of circular RNAs in aging-related sepsis and organ damage. The award aims to determine the function and mechanisms of an aging-induced circular RNA called circ20033 in promoting pro-inflammatory activation of macrophages after bacterial infections, as well as its role in lung inflammation in vivo. The...
This federal Project Grant award from the Department of Health and Human Services' National Institute on Aging (CFDA 93.866 - Aging Research) provides $331,187 to Brandeis University to conduct research on the role of retrotransposon activity in aging and age-related phenotypes. The project aims to establish a Drosophila model system to understand whether transposon activity is a cause or effect of the aging process. The research will complement existing work on the molecular underpinnings of...
This $558,222 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the roles of the circular RNA CircHIPK3 and the RNA-binding protein HuR in modulating mitochondrial function and gut barrier integrity in the aging intestinal epithelium. The five-year grant, effective from September 1, 2024 to August 31, 2029, will be carried out by researchers at the University of Maryland, Baltimore. The key objectives are to: 1) examine how CircHIPK3...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,274,632 to Epicypher, Inc. to develop a novel approach called CUTANA-RH for genome-wide profiling of R-loops. R-loops are triple-stranded nucleic acid structures involved in gene regulation, aging, and neurodegenerative diseases. The CUTANA-RH technology leverages a specialized RNA-DNA hybrid detection reagent to precisely map the genomic distribution of R-loops, enabling more...
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $660,908 to Brandeis University over 5 years (12/1/2024 - 11/30/2029) to uncover the functions of circular RNAs (circRNAs) in aging. The key products and services to be delivered under this grant include:

Determining the mechanisms behind circRNAs that promote aging, investigating the extent and requirements for circRNA translation and its relationship to aging, and defining the relationship between the FOXO regulon (a key regulator of aging and translation) and circRNAs in aging. The university has previously developed new tools to knockdown specific circRNAs and identified several circRNAs that can impact lifespan when knocked down. This project aims to expand on these initial findings and provide mechanistic insights into the interplay between circRNAs and aging pathways. The research findings are expected to illuminate key regulatory mechanisms of circRNA translation and their connections to the aging process.

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