This Project Grant award, funded by the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research, is providing $239,338 to the University of Alabama at Birmingham (UAB) to investigate the role of tRNA-derived short and long RNAs in the aging process. The project aims to determine if these RNA species contribute to lifespan or proteostasis changes associated with aging, through studies in the yeast model organism. Key aspects include overexpressing or depleting the tRNA-derived short RNAs (tRNA halves) to assess their effects, as well as characterizing the extended tRNA transcripts that accumulate with age. This exploratory research, running from July 2024 to June 2026, brings together experts in yeast aging and tRNA biology to elucidate potentially novel mechanisms underlying the aging phenotype. A subaward of $542,804 has also been provided to the University of Virginia to support this collaborative project.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $239.3k | 7/11/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
000542804SC001SMIS | Rector & Visitors Of The University Of Virginia | Project Grant R21AG085888 | $108.1k | 9/3/24 |