This Project Grant award from the National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) federal grant program, provides $660,908 in funding to Brandeis University to conduct research aimed at uncovering the functions of circular RNAs (circRNAs) in the aging process. The key focus areas of the research project are: 1) determining the mechanisms behind circRNAs that promote aging, 2) examining the extent and requirements for circRNA translation and its relationship to aging,...
This federal Project Grant award from the Defense Health Agency, under the Military Medical Research and Development program (CFDA 12.420), provides $1,635,000.00 to Trustees of Boston University's Boston University Medical Campus to conduct research on the "Circular RNA Repertoire Regulates Host Defense Against Bacterial Sepsis and Lung Injury." The research aims to advance scientific understanding of the molecular mechanisms involved in host defense against bacterial sepsis and...
The National Institute on Aging (NIA) awarded a $558,222 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Maryland, Baltimore to investigate the roles of the CircHIPK3 circular RNA and the HuR RNA-binding protein in regulating intestinal barrier function during aging. The 5-year research project (Sep 2024 - Aug 2029) aims to elucidate how CircHIPK3 and HuR modulate mitochondrial function in the aging intestinal epithelium, and how these molecular...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $408,600.00 to Trustees of Tufts College, doing business as Tufts University School of Medicine, to conduct research on the role of cytosolic DNA sensing in regulating tissue-resident macrophage function and organismal longevity. The key objectives of this research project are to: 1) Ascertain the role of endogenous retroelements in shaping tissue-resident macrophage survival and...
This National Institute on Aging (CFDA 93.866 Aging Research) Project Grant award of $412,500 to the Trustees of Boston University (Boston University Medical Campus) will fund research to investigate the "vicious cycle" between disruption of chromatin architecture, activation of retrotransposable elements (RTEs), and misexpression of CpG island-deficient genes during the aging process. The research aims to validate the mutual activation between chromatin architecture disruption and RTE...
The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $460,625 Project Grant to the University of Massachusetts Medical School (UMass Medical) on May 15, 2025. The grant will fund a 2-year research project titled "Platelet-MLKL Role in S100 Release with Age and Infection" that aims to investigate the mechanisms by which advanced age and respiratory viral infections, such as influenza, SARS-CoV-2, and RSV, contribute to thrombotic outcomes....
This Project Grant award, valued at $190,278.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The objective of this 5-year project, which commenced on February 1, 2025, is to investigate the role of transposable elements in septic immune aging. Specifically, the research aims to: 1) examine the dynamics of transposable element de-repression as a function of age and sepsis, 2)...
The National Institute on Aging (CFDA 93.866) awarded a $1,274,993 Project Grant to Epicypher, Inc. to develop a new approach called Reverse Transcribe & Tagmentation (RT & TAG) for identifying chromatin-associated RNAs (CARNAs), including nascent RNA transcripts, to accelerate aging and Alzheimer's disease/age-related dementia (AD/ADRD) research. The central innovation is an immunotethering-based method for in situ targeted tagmentation of CARNAs. The project also involves developing...
This Project Grant award, totaling $639,740, was provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) federal grant program. The research aims to explore the role of the CD38 enzyme and CD8 tissue resident memory (TRM) cells in the development of chronic lung fibrosis following viral pneumonia, including COVID-19. The primary awardee, the University of Virginia, will conduct studies to determine if targeting CD38 could mitigate age-associated chronic lung...
This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) in the amount of $448,270 supports research on the role of alveolar type II (ATII) cell senescence in the pathogenesis of influenza in aging populations. The Ohio State University will conduct this 2-year research project aimed at defining the effects of aging, influenza virus infection, and a potential therapeutic treatment (CDP-choline) on ATII cell function, energy metabolism, and...