This Project Grant award R01AG087407 from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) supports research to develop a novel, non-invasive 3D MRI technique to study intrinsic cerebrospinal fluid (CSF) outflow metrics in healthy older adults, mild cognitive impairment (MCI), and Alzheimer's disease (AD) patients. The $2,215,724 award to the University of California, San Diego aims to: 1) identify detailed CSF outflow pathways, 2) obtain quantitative measures of intrinsic CSF outflow in various brain regions, 3) compare CSF outflow in MCI/AD patients versus healthy controls, and 4) investigate any hemispheric differences in CSF outflow and correlate with physical activity levels. The project seeks to improve understanding of how impaired glymphatic clearance may contribute to cognitive decline, with the goal of developing new diagnostic markers and therapeutic approaches for AD. The award period is May 15, 2024 to January 31, 2029.
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