This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to study the mechanisms of synaptic resilience to tau pathology in Alzheimer's disease. The $1,003,116 award to the University of Alabama at Birmingham will support research to identify cellular pathways and therapeutic protein targets that can modulate tau seeding, tau-induced synaptic dysfunction, and synapse preservation. The project seeks to understand how some older individuals with Alzheimer's...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $137,895 to researchers at the University of California, Berkeley to investigate the network drivers of regional vulnerability to early Alzheimer's disease pathology. The key objectives are to use positron emission tomography (PET) imaging and resting-state functional MRI (rsfMRI) to examine how functional brain network connectivity is associated with Alzheimer's disease risk,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,592,854 to the University of Illinois to conduct research on tau protein conformation and its role in neurodegenerative diseases like Alzheimer's. The central hypothesis is that pathogenic forms of tau represent misregulation of normal tau functions as a scaffold for signaling pathways. The 2-year project aims to define the effects of tau post-translational modifications on tau function and...
This $866,723 federal Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to The Johns Hopkins University aims to improve understanding of the unique vulnerability of certain brain cell populations to Alzheimer's disease (AD) pathology. The grant will integrate high-field post-mortem brain imaging, histological analysis, and spatial transcriptomics to investigate how AD-related tau pathology and gene expression changes in the entorhinal cortex are associated...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $1,100,000 in funding to the University of Texas Medical Branch at Galveston to support research into the mechanisms of pathological tau spreading in Alzheimer's disease. The project aims to determine how amyloid-beta oligomers modulate the binding and internalization of toxic tau oligomers to vulnerable synapses, which is a key component of the trans-synaptic spread of tau...
This $2,500,027 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development of the Tau Progression Index (TPI), a novel prognostic score that can predict tau accumulation, neurodegeneration, and cognitive/functional decline in Alzheimer's disease (AD). The key products and services to be delivered under this 5-year award include: Recruiting 130 non-demented participants with evidence of amyloid-beta and tau pathologies based on PET...
The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD). The project aims to develop new...
This federal Project Grant award from the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, provides $816,661 to The Regents of the University of California, San Francisco to conduct research on the molecular and cellular mechanisms by which pathological tau protein drives neurodegeneration in Alzheimer's disease (AD) and related tauopathies. The project will leverage expertise in mass spectrometry-based proteomics and functional genomics to comprehensively map the impact of...
This $459,076 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) aims to identify early transcriptional and pathological changes in vulnerable brain regions during the prodromal stage of Alzheimer's disease (AD). The primary awardee, Trustees of Boston University, will perform single-nucleus RNA sequencing and targeted mass spectrometry analyses on postmortem brain samples from individuals with early-stage AD pathology. This will yield a...
This Project Grant award of $408,638 from the National Institute on Aging under the Aging Research program (CFDA 93.866) supports research to investigate the effect of trans-synaptic spread of pathogenic tau protein in Alzheimer's disease (AD) and other neurodegenerative diseases. The research, led by Virginia Commonwealth University, will utilize adeno-associated viral vector transfection, immunofluorescence, and cellular electrophysiology to examine the vulnerability of specific hippocampal...