Project Grant R01AG102578
Award Date 9/1/26
Completion Date 8/31/31
Dollars Obligated $522K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Jacksonville, FL 32224, USA
Similar Awards
- The National Institute on Aging awarded the University of Florida $422,125 on June 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how pathological tau protein affects RNA translation and neuronal function in tauopathies, including progressive supranuclear palsy and Alzheimer's disease. The research will identify RNA transcripts that bind to tau in primary tauopathies, characterize newly translated proteins in the presence of pathological tau, and examine tau-RNA...
- The National Institute on Aging awarded the University of Florida $5.551 million on July 1, 2026, under the Aging Research program (CFDA 93.866) to identify neural signatures that distinguish early Alzheimer's disease from normal aging. The recipient will record electrical activity from ten brain regions across the lifespan in human tauopathy mouse models (HTAU mice) and wild-type controls (C57BL/6J), computing new electrical oscillatory features called electome factors to distinguish between...
- The National Institute on Aging, a component of the Department of Health and Human Services, awarded Massachusetts Institute of Technology $596,050 on September 15, 2026, under the Aging Research program (CFDA 93.866) to investigate fuzzy coat dynamics of post-translationally modified tau aggregation. The project examines structural properties of tau, a microtubule-associated protein whose aggregation hallmarks Alzheimer's disease and twenty other neurodegenerative diseases. The research tests...
- The National Institute on Aging awarded The Regents of the University of California, San Francisco $681,908 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate protective mechanisms of UFM1-dependent IRE1 signaling in tauopathies, with work performance in San Francisco, California through November 30, 2030. The project addresses tau protein aggregation in Alzheimer's disease and related tauopathies by elucidating molecular mechanisms linking the ufmylation pathway...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded the University of Florida $119,502 on August 5, 2026, under the Aging Research program (CFDA 93.866) to support a K99 Project Grant (K99AG095151) investigating tau pathology in Alzheimer's disease through multi-omics approaches. The award funds research using spatial transcriptomics and metabolomics technologies to determine how pathological tau mediates disease spread from brainstem serotonin-producing raphe nuclei to healthy brain regions. The research...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $154,960 to the University of Kansas Medical Center Research Institute, Inc. on February 26, 2026, under the Aging Research program (CFDA 93.866). The recipient will conduct research combining cellular and clinical measures to examine bioenergetic contributions to tau phosphorylation in aging and Alzheimer's disease. The work leverages existing clinical data from the KU...
- The National Institute on Aging awarded The Regents of the University of California, San Francisco $663,237 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support multiscale structural approaches defining tau filaments and cellular dysfunction associated with Alzheimer's disease and related dementias (ADRDs). The research integrates histological and structural imaging methods with cryo-electron microscopy to characterize tau fibril structures, aggregate morphologies, and...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Regents of the University of California, San Francisco $194,573 on February 20, 2026, under the Aging Research program (CFDA 93.866) to investigate mechanisms of microglial-mediated sex-based differences in tauopathy. The recipient will conduct basic research examining how gonadal hormones contribute to sex-based differences in tau-related neurodegeneration through their effects on microglia, the...
- The National Institute on Aging awarded The Johns Hopkins University $653,100 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate poly(ADP-ribose) polymerase 1 (PARP1) and macrophage migration inhibitory factor (MIF) nuclease activity in tau-related neurodegeneration and cognitive dysfunction. The research will examine neurobehavior and neuropathology in PS19 transgenic mice models with PARP1 knockout and MIF nuclease-deficient or tautomerase-deficient genetic...