The National Institute on Aging (NIA) awarded a $2,356,117 Project Grant (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University to study the usage of novel linked databases to improve the perioperative management of patients with Alzheimer's disease and related dementias. The project aims to: (a) identify the extent to which surgical patients with Alzheimer's disease and related dementias (ADRD) are at increased risk for adverse postoperative outcomes, and (b) estimate the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,137,836 to The Leland Stanford Junior University to investigate the role of epigenetics in the pathogenesis of post-operative delirium (POD) and its relationship to long-term cognitive decline in elderly dementia patients.
The objective is to identify potential epigenetic biomarkers, specifically DNA methylation changes, that could predict the risk of POD and subsequent patient...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support Dr. Michael Devinney's research to determine the role of cerebrospinal fluid complement activation in delirium and post-intensive care unit (post-ICU) long-term cognitive impairment. The $180,252 award to Duke University will leverage a unique perioperative cerebrospinal fluid biorepository and recruit a cohort of 120 older ICU patients to assess cerebrospinal fluid complement activation,...
This Project Grant from the National Institutes of Health National Institute on Aging provides $4,489,362 to Duke University from September 15, 2022 through August 31, 2025 under the Aging Research program (CFDA 93.866). The grant will fund research to identify mechanisms of blood-brain barrier dysfunction in delirium superimposed on dementia after surgery. Specifically, the researchers will characterize how the postoperative systemic environment impacts the blood-brain barrier using...
This $125,847 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research program) supports research by The Leland Stanford Junior University to characterize biopsychological mismatch during cognitive training in individuals with mild cognitive impairment (MCI).
The key objective is to develop a new framework for quantifying biopsychological mismatch, measured as mental energy, task absorption, and autonomic adaptation, and examine how this mismatch relates to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the impact of interleukin-6 (IL-6) trans-signaling on the development of perioperative neurocognitive disorders (PNDs) in aged and Alzheimer's disease mouse models. The $1,117,062 award to the Regents of the University of California, San Francisco (UCSF) will run from September 15, 2024 to May 31, 2029. The research aims to determine if vulnerability to PNDs is...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $499,968.00 to Pascall Systems, Inc. to develop an integrated brain monitoring system for personalized anesthesia decision support to prevent postoperative delirium in elderly and at-risk patients.
The key products and services to be delivered under this award include: 1) establishing technical feasibility for integrating the brain monitoring system with electronic medical records, infusion...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) aims to investigate the role of perineuronal nets (PNN) in the development of postoperative delirium in aged mice. The $161,500 award, effective July 15, 2024 through June 30, 2026, will fund research to determine if changes in PNN quantity and composition coincide with delirium-like cognitive impairment in aged mice following exposure to anesthesia, surgery, and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $243,000.00 over 5 years starting August 1, 2024 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the relationship between delirium and biological age in older adults with traumatic brain injury (TBI). The goal is to understand how biological age metrics relate to post-traumatic delirium risk, and how delirium impacts longitudinal cognitive and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $2,342,815 will fund a study entitled "Delirium Dynamics: Understanding Causes and Effects" at Northwestern University. The research project aims to apply novel continuous monitoring techniques to investigate how specific disturbances in sleep-wake activity and circadian rhythms impact the acute fluctuations and long-term cognitive outcomes of delirium in...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $805,295 to The Leland Stanford Junior University to conduct a 5-year study examining cerebrospinal fluid (CSF) and blood biomarkers to gain insight into postoperative delirium and neurocognitive dysfunction. The key objectives are to:
Determine if CSF biomarkers of baseline risk, blood-brain barrier injury, inflammation, neuronal injury, and astrocyte injury/astrocytosis are associated with postoperative delirium (Aim 1) and neurocognitive dysfunction (Aim 2).
Examine the associations of blood biomarkers with delirium and neurocognitive dysfunction, and the correlations of serial blood and CSF biomarkers (Aim 3).
This study aims to provide a unique dataset of serial CSF and blood samples to explore how blood-brain barrier injury, inflammation, and brain injury contribute to postoperative cognitive impairment. The results are expected to provide insights into the utility of blood-based biomarkers for detecting and monitoring these conditions.