Project Grant R01AG089578
- This $1,425,000 project grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into neuronal senescence and inflammation in Alzheimer's disease. The Salk Institute for Biological Studies will study the interaction between cellular senescence and inflammation in induced neurons derived from Alzheimer's patients and healthy aged controls. Researchers will examine differences in gene expression and epigenetic...
- The National Institute on Aging awarded the Scripps Research Institute $2.613 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to investigate a druggable mito-nuclear feedback mechanism that preserves mitochondrial and synaptic function in aging and Alzheimer's disease. The research focuses on elucidating how age and pathological tau destabilize a brain-specific mito-nuclear feedback loop that controls mitochondrial gene expression in response to acetyl-CoA...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $442,750 to the University of California, Davis on September 1, 2026, under the Aging Research program (CFDA 93.866, assistance type: Project Grant) to investigate galectin-12's role in neuroinflammation and Alzheimer's disease progression. The funded research examines how metabolic stress triggers Alzheimer's disease by enhancing inflammation, with a focus on lipid droplet...
- The National Institute on Aging awarded The Jackson Laboratory $716,579 on December 15, 2025, under the Aging Research program (CFDA 93.866) to conduct genetic dissection of microglia functions in complement-mediated synapse loss in Alzheimer's disease. The award funds basic neuroscience research examining how microglia—the brain's resident macrophages—trigger neuronal synapse loss through complement cascade activation in Alzheimer's disease models. The project addresses three knowledge gaps:...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $170,668 to the University of California, San Diego on October 24, 2025, under the Aging Research program (CFDA 93.866) to support research into s-nitrosylated phospholipase D3 in Alzheimer's disease pathophysiology. The funded research investigates the mechanistic role of s-nitrosylated phospholipase D3 (SNO-PLD3) in Alzheimer's disease. The work builds on prior mass spectrometry findings that...
- The National Institute on Aging, an office of the National Institutes of Health, awarded the University of California, Davis $683,331 under the Aging Research program (CFDA 93.866) on September 1, 2026, to identify and validate causal risk genes and proteins contributing to Alzheimer's disease and its neuropsychiatric symptoms. The research integrates genome-wide association study (GWAS) findings with functional omics data from post-mortem brain tissues to pinpoint proteins mediating Alzheimer's...
- The National Institute on Aging awarded $1,212,742 to the Sloan-Kettering Institute for Cancer Research on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate epichaperomes as a mechanism for restoring drug responsiveness in Alzheimer's disease. The research tests the hypothesis that epichaperome inhibition with PU-AD restores synaptic architecture and re-enables responsiveness to levetiracetam (LEV), a therapy whose efficacy depends on properly localized SV2A...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $704,145 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and apply computational methods for inferring the natural history of Alzheimer's disease from sparse longitudinal molecular and neuroimaging data. The recipient will develop an innovative approach that leverages temporal signal in sparse longitudinal datasets to reconstruct the timeline of Alzheimer's disease progression and...
- The National Institute on Aging awarded The Jackson Laboratory $354,000 on March 15, 2026, under the Aging Research program (CFDA 93.866) to develop an automatable protocol for creating human induced pluripotent stem cell-derived microglia and their co-culture with primary astrocytes from Alzheimer's disease patients. The project, titled "Discovery of Disease-Associated eQTLs with a Scalable Human In Vitro Model of Microglia-Astrocyte Interactions," aims to identify which of the...
The National Institute on Aging awarded The Salk Institute for Biological Studies $772,971 on September 1, 2026, for multi-omics analysis of astrocytes in Alzheimer's disease to identify targets to prevent synapse loss under the Aging Research program (CFDA 93.866). The research tests the hypothesis that alterations to synapse-supportive roles of astrocytes in Alzheimer's disease contribute to synaptic dysfunction and disease pathogenesis. The project employs in vivo cell-type specific RNA sequencing, proximity labeling proteomics with TurboID, and in vivo protein overexpression to rescue synaptic dysfunction across three aims: determining if correcting individual dysregulated astrocyte-secreted proteins restores synaptic function; testing whether correcting global protein secretion alterations is beneficial; and identifying the full repertoire of astrocyte-secreted protein alterations in Alzheimer's disease. Preliminary work identified transcriptomic and proteomic profiles of astrocytes across disease progression in two mouse models—an amyloidosis model (APP/PS1) and a tauopathy model (P301S)—revealing common and unique alterations to astrocytes in the presence of amyloid and tau pathology. The research focuses on astrocyte-secreted proteins and synapse regulation, including astrocyte glypican 5 (GPC5), which in healthy brain promotes synapse maturation and stabilization but is downregulated with disease progression. The period of performance runs from September 1, 2026, through May 31, 2031. Work is performed in La Jolla, California. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $773.0k | 8/19/26 |