This $825,135 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the Massachusetts General Hospital to investigate the relationships between gut microbiome-related metabolites, cerebrovascular disease, Alzheimer's disease biomarkers, and cognitive impairment. The research will leverage data from the REGARDS and CARDIA longitudinal cohort studies to examine associations between gut microbiome metabolites, brain imaging markers, and the incidence and trajectory of cognitive decline. The project will also determine the effect of gut-related metabolites on the relationship between amyloid-beta biomarkers and cognitive impairment. The award includes sub-grants to the University of Alabama at Birmingham and the University of Cincinnati to provide specialized services such as MRI data analysis, cognitive assessment, and data integration. This multi-institutional research effort aims to gain insights into the mechanisms linking diet, gut microbiome, and the development of cognitive impairment, which could inform future intervention strategies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $825.1k | 9/5/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
246368S | University Of Alabama At Birmingham | Project Grant R01AG089361 | $167.0k | 11/11/24 | |
246368S | Cincinnati Univ Of | Project Grant R01AG089361 | $40.5k | 11/4/24 |