Project Grant R01AG089361

Award Date 9/15/24
Completion Date 7/31/29
Dollars Obligated $825K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Boston, MA 02114, USA
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Massachusetts Medical School is focused on understanding how the gut microbiome influences neurodegeneration and protects against Alzheimer's disease. The $647,979 award, effective September 30, 2024 through August 31, 2025, will leverage the C. elegans model system to: Determine how bacterial production of vitamin B12 protects against neurodegeneration pathways. Examine...
The National Institute on Aging (NIA) awarded a $856,580 Project Grant (CFDA 93.866 - Aging Research) to the University of Massachusetts Lowell to elucidate the microbial origins of Alzheimer's disease and related dementias (AD/ADRD) in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort. The project will generate longitudinal gut microbiome and serum metabolomic profiles for approximately 2,800 HCHS/SOL participants to investigate the role of the gut microbiome in AD/ADRD...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to the University of South Florida will support research to determine the role of gut-derived microRNAs (miRNAs) in age-related cognitive decline and Alzheimer's disease and related dementias (ADRD). The $849,904 award, effective September 30, 2024 through August 31, 2026, will fund studies to identify unique miRNA signatures in the blood of older adults with mild cognitive impairment (MCI) and dementia...
This $1,102,206 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a research project titled "CRCNS: Repurposing Transformers to Characterize Gut Microbiome & Aging Brain Axis" at the University of Wisconsin - Madison. The project aims to design specialized transformer-based machine learning models to analyze associations between gut microbiome composition and brain health in Alzheimer's disease and other dementias. Key objectives...
The National Institute on Aging (NIA) awarded a $502,045 Project Grant (CFDA 93.866 - Aging Research) to the University of Wisconsin-Madison to test the safety and feasibility of a custom probiotic intervention among people with Alzheimer's disease (AD) dementia and preclinical AD. The study aims to evaluate secondary outcomes, such as cognitive function and plasma biomarkers, and explore potential mechanisms by which gut microbiome modulation may impact the brain in AD. The research will be...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $630,905 to the University of Wisconsin-Madison to explore the role of the gut microbiome-derived metabolite imidazole propionate (IMP) in the progression of Alzheimer's disease (AD) and related dementias (ADRD). The central hypothesis is that IMP modulates AD and ADRD pathology by altering vascular endothelial function and blood-brain barrier permeability. The research will...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $696,896 to the University of Texas Health Science Center at Houston to conduct research on the impact of the gut microbiome on B cell-mediated neuroinflammation in cerebral amyloid angiopathy (CAA). The research aims to investigate three key hypotheses: (1) CAA induces B cell-driven inflammation in the brain; (2) CAA-induced gut dysbiosis can promote B cell-mediated neuroinflammation...
The University of South Florida received a $3,385,215 Project Grant award from the National Institute on Aging, part of the National Institutes of Health within the Department of Health and Human Services. The grant was awarded under the Aging Research program (CFDA 93.866) to fund research titled "Microbial Therapy Improves Gut Permeability to Reduce Cognitive Decline and Alzheimer's Disease." The grant will support research from August 2021 through July 2024 to study the impact of...
The University of Alabama at Birmingham (UAB) has been awarded a $1,869,019 Project Grant by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The funding will support a 3-year research project to investigate the role of circadian rhythms, gut microbiome, and gut-to-brain signaling in the onset and progression of Alzheimer's disease (AD) using a Drosophila (fruit fly) model. Key objectives include determining whether depletion of gut microbiota...
This $484,314 Project Grant was awarded by the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074). The funding will support research at Christopher Newport University to investigate the "microbiota-gut-brain axis" and the impact of intestinal barrier dysfunction on aging and neurodegeneration. Key objectives include gaining insights into the cellular and molecular changes associated with an aging gut, how...

This $825,135 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the Massachusetts General Hospital to investigate the relationships between gut microbiome-related metabolites, cerebrovascular disease, Alzheimer's disease biomarkers, and cognitive impairment. The research will leverage data from the REGARDS and CARDIA longitudinal cohort studies to examine associations between gut microbiome metabolites, brain imaging markers, and the incidence and trajectory of cognitive decline. The project will also determine the effect of gut-related metabolites on the relationship between amyloid-beta biomarkers and cognitive impairment. The award includes sub-grants to the University of Alabama at Birmingham and the University of Cincinnati to provide specialized services such as MRI data analysis, cognitive assessment, and data integration. This multi-institutional research effort aims to gain insights into the mechanisms linking diet, gut microbiome, and the development of cognitive impairment, which could inform future intervention strategies.

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