This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to determine how the gut microbiome influences neurodegeneration and protects against Alzheimer's disease. The $647,979 award to the University of Massachusetts Medical School (UMass Medical) will leverage the C. elegans model system to: Investigate how bacterial production of vitamin B12 protects against neurodegeneration induced by the TIR-1/SARM1 pathway. Determine how the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Wisconsin-Madison for $1,102,206 will fund research to characterize the relationship between the gut microbiome and the aging brain, with a focus on Alzheimer's disease and other neurodegenerative conditions. The key components of the project include: Developing specialized transformer-based machine learning models to analyze associations between gut microbiome composition and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $825,135 supports research to examine the relationship between gut microbiome-related metabolites, cerebrovascular small vessel disease, and cognitive impairment. The award, granted to The General Hospital Corporation (doing business as Massachusetts General Hospital), aims to: Investigate the association between gut microbiome metabolites and cerebrovascular small vessel disease...
This federal Project Grant award of $10,847,672 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to the J. David Gladstone Institutes to conduct research on the mechanisms of cerebral amyloid angiopathy (CAA) and its relationship to Alzheimer's disease pathology. The award will fund a multidisciplinary research effort to profile human postmortem brain samples using advanced single-cell and spatial genomics techniques, while also leveraging mouse models to...
The University of South Florida received a $3,385,215 Project Grant award from the National Institute on Aging, part of the National Institutes of Health within the Department of Health and Human Services. The grant was awarded under the Aging Research program (CFDA 93.866) to fund research titled "Microbial Therapy Improves Gut Permeability to Reduce Cognitive Decline and Alzheimer's Disease." The grant will support research from August 2021 through July 2024 to study the impact of...
This Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), is funding the development of neuroprotective engineered bacteria as a therapeutic approach for Alzheimer's disease (AD). The $906,019 grant, awarded on September 25, 2024, will support Bloom Science, Inc., a minority-owned and woman-owned small business, in three key aims: Validating the efficacy of a cocktail of anti-inflammatory compounds (butyrate, beta-hydroxybutyrate, and...
This $849,904 federal Project Grant award from the National Institutes of Health's National Institute on Aging (CFDA 93.866 - Aging Research) will fund a research study titled "miRNAs in the Gut-Brain Axis to Predict the Risk of Cognitive Decline in Older Adults" at the University of South Florida. The study aims to determine unique signatures of gut-derived microRNAs (miRNAs) in the blood of older adults with mild cognitive impairment (MCI) and dementia, and investigate how these...
This $856,580 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study to elucidate the microbial origins of Alzheimer's disease and related dementias (AD/ADRD) among the Hispanic/Latino population. The study will leverage the existing Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort to collect longitudinal gut microbiome, blood metabolomic, and AD/ADRD biomarker data from approximately 360 participants across four field...
The University of Alabama at Birmingham (UAB) has been awarded a $1,869,019 Project Grant by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The funding will support a 3-year research project to investigate the role of circadian rhythms, gut microbiome, and gut-to-brain signaling in the onset and progression of Alzheimer's disease (AD) using a Drosophila (fruit fly) model. Key objectives include determining whether depletion of gut microbiota...
This $2,327,075 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research by Baylor College of Medicine on the role of the complement pathway in Alzheimer's disease (AD). The key objectives are to understand how the complement component C3 and its receptor C3AR regulate microglia metabolism and function in response to amyloid-beta pathology, as well as to decipher the relationship between the C3A-C3AR and TLQP-21-C3AR signaling pathways...