Project Grant R01AG088643

Award Date 7/1/25
Completion Date 4/30/30
Dollars Obligated $655K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Chicago, IL 60612, USA
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This $1,246,362 project grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Rush University Medical Center aims to elucidate the morphology and compositional changes of the perivascular pia mater (PVS PIA) in the human brain across aging and Alzheimer's disease. The 3-year project will leverage clinical and pathological data from the Rush Religious Orders Study and Memory and Aging Project to map PVS PIA anatomy using advanced microscopy techniques. Key...
This $4,361,625 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a collaborative research initiative led by Washington University in St. Louis to investigate the molecular mechanisms underlying cerebral small vessel disease (CSVD) and its vascular contributions to dementia (VCID). The project leverages three key resources: a large collection of cerebrospinal fluid samples, human brain tissue specimens, and advanced neuroimaging...
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This $654,910 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) will fund a study by Rush University Medical Center to identify molecular mechanisms underlying the contribution of cerebrovascular disease (CVD) pathologies to Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRD) in older adults.

The key objectives are to: 1) measure RNA transcription levels and proteins in deep frontal white matter to identify mechanisms linking CVD and AD pathologies to AD/ADRD; 2) use computational biology approaches to examine the relationships between the white matter molecular data and genetic risk factors for ischemic stroke and Alzheimer's dementia; and 3) compare the white matter findings to similar analyses of dorsolateral prefrontal cortex gray matter data. The 5-year project will leverage existing data from the Religious Orders Study and Rush Memory and Aging Project to generate new multi-omics data from 500 participants across discovery and validation cohorts.

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