Project Grant R01AG087945

Award Date 9/17/24
Completion Date 5/31/29
Dollars Obligated $2.9M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
New York, NY 10029, USA
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This $2,344,888 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to the Dian Fossey Gorilla Fund International, Inc. to investigate the influences of early life adversity on lifespan and individual frailty in wild chimpanzees and gorillas. The 5-year study, beginning September 2024, will leverage 170 years of detailed demographic and early life adversity data from approximately 400 wild chimpanzees and 485 wild gorillas across 3 distinct populations....
This Project Grant award, totaling $418,364.00, was issued by the National Institute on Aging (CFDA 93.866 - Aging Research) to Wake Forest University Health Sciences to conduct a comprehensive study on lifespan and biological aging across multiple nonhuman primate (NHP) species. The key objectives are: Generate the most accurate sex-specific lifespan and age-at-death distributions for 11 biomedically-relevant NHP species, and test the influence of factors like body size, age at reproductive...
The National Institute on Aging (NIA) awarded a $689,525 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to New York University (NYU) to investigate the integration of cell-specific microstructure within long-range brain networks in the macaque monkey. The project aims to disentangle cell-type specific signatures of brain microstructure using in vivo MRI techniques and determine how these signatures vary across individuals. This work will contribute to a...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research Federal Grant Program (CFDA 93.866) provides $1,394,250 to the Icahn School of Medicine at Mount Sinai to study the molecular mechanisms underlying pathological aging of the human brain and adipose tissue, as well as their inter-organ communication. The project aims to investigate the heterogeneity of human aging and identify the common pathological aging mechanisms shared between the brain (e.g., hippocampus,...
This $670,324 Project Grant award from the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) will support a research project titled "Social Modifiers of Primate Lifespan" at the University of Exeter in the United Kingdom. The objectives of this 5-year project are to: 1) Leverage the researchers' Bayesian life-history model, primate social network database, and epigenetic aging clock to estimate lifespans across over 70 primate species; 2)...
This National Science Foundation project grant of $417,856 supports research on understanding variation in primate aging patterns through March 2026. Funded under the Social, Behavioral, and Economic Sciences program (CFDA 47.075), the award to Stony Brook University will couple a longitudinal dataset on over 100 wild non-human primates with physiology, medical imaging, molecular, and comparative methods. The research aims to identify the trajectory of aging across the life course regarding...
This $4,950,026 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Icahn School of Medicine at Mount Sinai is investigating potential synergy between HIV infection and amyloid beta, a hallmark of Alzheimer's disease, in promoting memory impairment. Researchers will characterize enhanced HIV neuropathogenesis in familial and late-onset Alzheimer's disease mouse models...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,128,604.00 to The University of Texas MD Anderson Cancer Center to investigate the relationships between immunosenescence, brain aging biomarkers, and cognition across non-human primate species with differing lifespans. The project aims to elucidate the role of the immune system in longevity, neurodegeneration, and cognitive decline, which may inform the development of immuno-restorative...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of California, San Francisco (UCSF) provides $1,682,833 to study human-specific vulnerabilities and compensatory adaptations to age-related stressors in midbrain dopaminergic neurons. The primary goals are to: Measure dynamic gene regulatory responses and candidate protective pathways to age-related oxidative stress in human, chimpanzee, and rhesus macaque dopaminergic neurons using...
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The National Institute on Aging (NIA) awarded a $2,947,959 Project Grant (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai to examine the impact of cardiovascular health on longevity, brain function, and age-related diseases in humans and great apes. The key products and services to be delivered under this 5-year award include:

Evaluating the effects of aging, cardiovascular disease, and neurovascular health on brain structure and function in humans and great apes using stereology, electron microscopy, and immunofluorescence imaging. Identifying associations between age-related vascular risk factors and cognitive impairment in great apes through MRI brain scans and biomarker analyses. Examining how age and cardiovascular health influence cognition in chimpanzees compared to humans through retrospective and prospective analyses. The project involves sub-awards to GE Healthcare, George Washington University, MD Anderson Cancer Center, and Kent State University to provide specialized research services, including antibody validations, electron microscopy, histological processing, and data analyses.

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