This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) funds a study by New York University (NYU) School of Medicine to investigate the relationship between cellular-level microstructural changes and age-related alterations in long-range brain network connectivity in rhesus macaques. The $689,525 award, spanning 2 years from September 2024 to August 2026, will utilize a combination of in vivo MRI, ex vivo MRI, and histological analyses to establish morphological and microstructural signatures of brain regions connected by long-range anatomical projections. The study aims to understand how accelerated age-related decline in these high-demand cortical areas contributes to structural changes in brain networks. The project will develop a translational nonhuman primate reference dataset and network-based analyses to support future mechanistic studies on aging processes that cannot be easily examined in humans.
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