Project Grant R01AG087957

Award Date 7/22/24
Completion Date 6/30/29
Dollars Obligated $418K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Winston-Salem, NC 27157, USA
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The National Institute on Aging (NIA) awarded a $670,324 project grant (CFDA 93.866 - Aging Research) to the University of Exeter in the United Kingdom. The 5-year grant, commencing on Sep 15, 2024 and ending on Aug 31, 2029, aims to study the social modifiers of lifespan in primates. The key products and services to be delivered under this grant include: Developing a Bayesian life-history model to estimate lifespan for over 70 primate species, creating the largest database of primate...
The National Institute on Aging (NIA) has awarded a Project Grant (CFDA 93.866 - Aging Research) in the amount of $687,288 to the University of California, Berkeley to conduct comparative analyses of somatic mutational processes in primates across lifespans. The project aims to characterize somatic mutational landscapes and clonal dynamics in aging tissues across primate species with diverse lifespans, using advanced sequencing techniques like NanoSeq and PacBio. The research will generate a...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a study on the evolutionary origins of longevity in great apes. The $1,574,518 grant, awarded on September 15, 2024, will be used by the Dian Fossey Gorilla Fund International, Inc. to investigate how early life adversity influences lifespan and frailty in wild chimpanzee and gorilla populations. The study leverages over 170 years of detailed demographic and health data on approximately 400...
This National Science Foundation project grant of $417,856 supports research on understanding variation in primate aging patterns through March 2026. Funded under the Social, Behavioral, and Economic Sciences program (CFDA 47.075), the award to Stony Brook University will couple a longitudinal dataset on over 100 wild non-human primates with physiology, medical imaging, molecular, and comparative methods. The research aims to identify the trajectory of aging across the life course regarding...
This National Science Foundation project grant of $184,647 supports research on understanding variation in patterns of aging in primates through an integrative comparative approach. Funded under the Social, Behavioral, and Economic Sciences program (CFDA 47.075), the three-year award to Arizona State University will analyze biological aging trajectories and individual differences across the lifespan using a longitudinal dataset of over 100 wild-living non-human primates. Key products include...
This federal Project Grant award, with ID R01AG087945, was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The $1,055,607 grant is funding a 5-year research project to investigate the impact of cardiovascular health on longevity, the brain, and age-related diseases in humans and great apes, including chimpanzees, bonobos, gorillas, and orangutans. The project aims to evaluate the effect of aging, cardiovascular disease, and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $971,117 to establish a Coordinating Center for Primate Aging Research (CCPAR). The CCPAR will be jointly led by the Tulane National Primate Research Center, California National Primate Research Center, and Baylor College of Medicine. The key objectives are to: 1) Enhance the quality and public accessibility of projects funded under the related RFA, 2) Identify promising future...
This Project Grant award of $859,240.00, provided by the National Institute on Aging under the Aging Research Federal Grant Program (CFDA 93.866), supports research investigating the relationships between immunesenescence, brain aging biomarkers, and cognition across nonhuman primate species with differing lifespans. The primary awardee, The University of Texas MD Anderson Cancer Center, will conduct studies to better understand the role the immune system plays in longevity, neurodegeneration,...
The National Institute on Aging (NIA) awarded a $312,900 Project Grant (CFDA 93.866 - Aging Research) to the University of Oregon to support research on the genetic basis of exceptional longevity and healthy aging in the model organism Caenorhabditis elegans. The 5-year project, running from August 1, 2024 to April 30, 2029, aims to: 1) Identify the genetic drivers of extended lifespan in a naturally long-lived C. elegans isolate, 2) Develop tissue-specific "aging clocks" to assess...
The National Institute on Aging awarded a $433,950 Project Grant (CFDA 93.866 - Aging Research) to the University of California, Davis to develop a lifespan rhesus monkey model for studying interoception, the ability to sense and process internal physiological signals. The project aims to establish a translatable animal model for interoceptive processes that deteriorate with aging, which is critical for understanding the neurobiological mechanisms and developing interventions for...

The National Institute on Aging (NIA) awarded a $418,364 Project Grant (CFDA 93.866 - Aging Research) to Wake Forest University Health Sciences (WFUHS) to conduct a comprehensive study on lifespan and healthspan factors in nonhuman primates (NHPs). The objectives are to:

  1. Generate sex-specific lifespan and age-at-death distributions for 11 biomedically-relevant NHP species to understand the influence of energetic trade-offs on longevity.

  2. Identify shared and species-specific patterns of biological aging across 15,000 NHP lifespans using a deficit accumulation index from clinical blood chemistries.

  3. Leverage genomic and proteomic data to characterize the biological pathways and innate risk factors driving longevity differences within and between NHP species.

This 5-year grant will leverage the extensive Nonhuman Primate Lifespan Project dataset and leverage a sub-award to the Texas Biomedical Research Institute to perform the NHP lifespan analyses. The findings aim to advance the scientific understanding of the genetic, demographic, and physiological factors influencing aging and lifespan in nonhuman primates.

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