Project Grant R01AG086475
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $2,957,210 to The Trustees of Columbia University in the City of New York (Health Sciences Division) on September 15, 2025, under the Aging Research program (CFDA 93.866) to support research examining the role of CD44-expressing astrocytes in Alzheimer's disease pathology. The research addresses a critical gap in understanding how astrocyte dysfunction contributes to Alzheimer's disease...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York $6.9 million through the Aging Research program (CFDA 93.866) for a four-year project running from August 1, 2025, through July 31, 2029. The award funds research to develop a multi-organ chart of personalized susceptibility to Alzheimer's disease and aging using large-scale multi-omics, multi-organ biomedical data, and advanced artificial...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $475,377 to The Trustees of Columbia University in the City of New York (Health Sciences Division) on September 5, 2025, under the Aging Research program (CFDA 93.866). This award supports a two-year research project extending through August 31, 2027, investigating the functional significance of microglial FOXO3 (Forkhead Box O-3) in Alzheimer's disease (AD). The research addresses the critical...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded $852,273 to The Trustees of Columbia University in the City of New York, Health Sciences Division, through the Aging Research program (CFDA 93.866) on September 1, 2025, for a project extending through May 31, 2030. This Project Grant funds a comprehensive genetic mapping study investigating the role of RNA modifications—specifically N6-methyladenosine (M6A) and pseudouridine (Ps)—in Alzheimer's disease (AD) pathogenesis...
- Federal Project Grant Award Summary The Trustees of Columbia University in the City of New York received a $452,375 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective January 1, 2026, with a completion date of December 31, 2027. This research grant supports a two-year investigation titled "Role for Semaphorin 3A in Microglial Activation and Alzheimer's Disease." The project will deliver scientific research and analysis...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $472,073 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) beginning September 1, 2025, with completion targeted for May 31, 2030. Under the Aging Research program (CFDA 93.866), this award funds scientific research investigating the role of tau-induced changes in post-translational modifications—specifically sumoylation and succinylation—in mitochondrial-nuclear...
- Federal Grant Award Summary The National Institute on Aging awarded a $2.49 million Project Grant to the University of California, Irvine under the Aging Research program (CFDA 93.866) on September 15, 2025, with a completion date of August 31, 2029. This award supports fundamental research investigating circuit vulnerability of the lateral and medial entorhinal cortices in tauopathy models relevant to Alzheimer's disease (AD). The project will utilize two tau mouse models to identify entorhinal...
- Federal Project Grant Award Summary New York University School of Medicine received a $130,302.00 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded July 15, 2025, with a project completion date of March 31, 2030. The grant funds scientific research directed toward understanding the selective vulnerability of basal forebrain cholinergic neurons (BFCNs) to tau pathology in Alzheimer's disease. The research deliverables include...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York a Project Grant totaling $6.29 million under the Aging Research program (CFDA 93.866) for the period August 1, 2025 through July 31, 2029. This research project investigates the functional and regulatory mechanisms of proteasome complexes across multiple neurodegenerative diseases, with primary focus on Alzheimer's disease (AD), Progressive Supranuclear Palsy...
- Federal Grant Award Summary New York University School of Medicine received a $642,063 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 15, 2026, through December 31, 2030. The grant supports scientific research investigating GABAergic (gamma-aminobutyric acid) circuit targets for modulating entorhinal cortex and hippocampal dynamics in Alzheimer's Disease. The research deliverables include a cross-species comparison...
The National Institute on Aging (NIA) awarded Columbia University's Health Sciences Division a $529,744 Project Grant effective February 15, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). The award funds research investigating the mechanisms driving Alzheimer's disease progression through the entorhinal cortex-hippocampal circuit. The primary deliverables include longitudinal scientific investigations utilizing two-photon in vivo microscopy imaging, targeted neuronal manipulation techniques, and mechanistic studies examining the relationship between neuronal hyperactivity, neuroinflammation, and tau pathology in disease progression models. The research products delivered under this award will advance understanding of why the entorhinal cortex exhibits early vulnerability in Alzheimer's disease and what drives disease progression. The project will generate novel data on layer 2 projection neuron activity patterns, the role of microglial activation in driving neuronal hyperactivity, and the causal relationship between these factors and tauopathy spread. Results from the three synergistic research aims will test the central hypothesis that tauopathy, neuroinflammation, and neuronal hyperactivity form a vicious cycle in the entorhinal cortex, potentially identifying new therapeutic targets for disease intervention and contributing to the NIA's mission of supporting research on Alzheimer's disease prevention and treatment.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $529.7k | 2/3/26 |