Project Grant R01AG086472

Award Date 12/1/24
Completion Date 11/30/29
Dollars Obligated $735K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Richardson, TX 75080, USA
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This Project Grant award of $2,495,639.00 from the National Institute on Aging (NIA) Aging Research program (CFDA 93.866) aims to develop a regenerative biomaterial therapy to treat Genitourinary Syndrome of Menopause (GSM), a highly prevalent condition affecting up to 85% of perimenopausal and menopausal women. The principal investigator at the University of California, San Diego will create a novel vaginal tissue-derived extracellular matrix hydrogel (VECM) and assess its efficacy in reversing...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $451,000 in funding to The University of Texas Southwestern Medical Center to investigate how estrogen modulates chondrocyte mechanotransduction via the PIEZO1 and TRPV4 channels. The research aims to define the sex-specific and estrogen-regulated role of these mechanosensitive channels in chondrocyte mechanotransduction, which may help identify new targets to treat and prevent...
The National Institute on Aging (NIA) awarded a $1,132,258 Project Grant (CFDA 93.866 - Aging Research) to Moremme VA LLC to develop a hormone-free, prebiotic, muco-adhesive gel for the treatment of vaginal atrophy in post-menopausal women. The goal is to optimize the loading and release of natural bioactives in the gel formulation, assess its safety and tolerability using human vaginal tissue models, and evaluate its efficacy in reversing signs of vaginal atrophy in animal studies. Upon...
The National Institute on Aging (NIA) awarded a $439,535 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Colorado from September 30, 2023 to September 29, 2025. This grant will fund research to investigate the interplay between active smooth muscle cell contractility and passive extracellular matrix mechanics in the aging bladder, with the goal of gaining insight into the development of lower urinary tract symptoms in older adults. The University...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $431,750 aims to isolate and characterize peptide ligands targeting vascular endothelial cells (VECs) in young versus aged mice in vivo and senescent versus non-senescent murine VECs in vitro. The primary objectives are to enhance the understanding of molecular mechanisms and age-related pathologies associated with vascular dysfunction during aging. The project seeks to...
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This Project Grant award of $848,100 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research to investigate the cellular mechanisms underlying recurrent vaginal prolapse after prolapse surgery. The primary objectives are to: 1) Examine the effect of pelvic organ prolapse (POP) surgery on the human vagina through tissue biomechanical testing,...
This federal Project Grant award of $416,625 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support research at Saint Louis University (SLU) to investigate the effects of aging, sex, and hormonal status on atherosclerotic cardiovascular disease (CVD). The key objectives are to: 1) comprehensively map inflammatory cell profiles and cell-cell communication networks in atherosclerotic plaques of young and old male and female mice, including old...
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