This Project Grant award of $2,495,639.00 from the National Institute on Aging (NIA) Aging Research program (CFDA 93.866) aims to develop a regenerative biomaterial therapy to treat Genitourinary Syndrome of Menopause (GSM), a highly prevalent condition affecting up to 85% of perimenopausal and menopausal women. The principal investigator at the University of California, San Diego will create a novel vaginal tissue-derived extracellular matrix hydrogel (VECM) and assess its efficacy in reversing...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $451,000 in funding to The University of Texas Southwestern Medical Center to investigate how estrogen modulates chondrocyte mechanotransduction via the PIEZO1 and TRPV4 channels. The research aims to define the sex-specific and estrogen-regulated role of these mechanosensitive channels in chondrocyte mechanotransduction, which may help identify new targets to treat and prevent...
The National Institute on Aging (NIA) awarded a $1,132,258 Project Grant (CFDA 93.866 - Aging Research) to Moremme VA LLC to develop a hormone-free, prebiotic, muco-adhesive gel for the treatment of vaginal atrophy in post-menopausal women. The goal is to optimize the loading and release of natural bioactives in the gel formulation, assess its safety and tolerability using human vaginal tissue models, and evaluate its efficacy in reversing signs of vaginal atrophy in animal studies. Upon...
The National Institute on Aging (NIA) awarded a $439,535 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Colorado from September 30, 2023 to September 29, 2025. This grant will fund research to investigate the interplay between active smooth muscle cell contractility and passive extracellular matrix mechanics in the aging bladder, with the goal of gaining insight into the development of lower urinary tract symptoms in older adults. The University...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $431,750 aims to isolate and characterize peptide ligands targeting vascular endothelial cells (VECs) in young versus aged mice in vivo and senescent versus non-senescent murine VECs in vitro. The primary objectives are to enhance the understanding of molecular mechanisms and age-related pathologies associated with vascular dysfunction during aging. The project seeks to...
The University of Texas at Dallas was awarded a $360,517 Project Grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation under the Engineering (47.041) federal grant program. The grant will support research titled "Physics-Informed and Geometry-Informed Machine Learning for Analysis of Multi-Scale Distensible Biological Structures" from September 2021 through August 2024. The research aims to develop new machine learning techniques...
This Project Grant award of $848,100 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research to investigate the cellular mechanisms underlying recurrent vaginal prolapse after prolapse surgery. The primary objectives are to: 1) Examine the effect of pelvic organ prolapse (POP) surgery on the human vagina through tissue biomechanical testing,...
This federal Project Grant award of $416,625 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support research at Saint Louis University (SLU) to investigate the effects of aging, sex, and hormonal status on atherosclerotic cardiovascular disease (CVD). The key objectives are to: 1) comprehensively map inflammatory cell profiles and cell-cell communication networks in atherosclerotic plaques of young and old male and female mice, including old...
The National Institute on Aging (NIA) awarded a $391,101 Project Grant under the Aging Research program (CFDA 93.866) to The Ohio State University to develop a novel nonsteroidal and nonhormonal agent that reverses menopause-related loss of genital epithelial integrity and function. The research aims to define the mechanism of action, optimize delivery, and establish the long-term safety profile of an EFNA3-mimetic agonist peptide (EFNA3-MAP) administered intravaginally to restore genital...
This $176,201 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at the University of California, Irvine to investigate urethral dysfunction and urinary incontinence in women. The key objectives are to (1) identify molecular changes in aging female urethral tissue, and (2) explore the role of the fibrogenic factor CTGF in age-related urethral muscle...