This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,343,725 to The Spaulding Rehabilitation Hospital Corporation to investigate the effects of muscle aging and activity on extracellular vesicle regulation of muscle regeneration. The primary goals are to: 1) examine how aging of the skeletal muscle extracellular matrix alters the molecular composition of muscle-derived extracellular vesicles and impacts muscle stem cell myogenicity and...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of aging. The project aims to evaluate how a population of mouse T cells can be iteratively boosted and passaged among young mice for over 11 years, exceeding the normal mouse lifespan, while retaining functional competence and proliferative potential. The research will investigate factors such as...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,127,548 to the University of Texas Medical Branch at Galveston to investigate the role of post-translational modifications of myosin and its chaperone UNC-45 in the development of sarcopenia, the age-related loss of muscle mass and function. The project aims to use a combination of in vitro biochemical and biophysical assays, as well as in vivo techniques in the C. elegans model organism,...
This Project Grant awarded by the National Institute on Aging (NIA) under CFDA 93.866 Aging Research supports research to explore the sex-specific determinants of muscle quality in older adults. The $116,710 award will fund a study at the University of Connecticut to directly measure muscle quality, neurological impairment, muscle adiposity, and muscle stiffness in 60 older adults, comparing 30 males and 30 females. The goal is to identify sex-specific therapeutic targets to improve muscle...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,055,313 in funding to the University of Miami to conduct research on the role of glial cells in the aging process. Specifically, the researchers will leverage C. elegans genetics and advanced imaging and supplementation methods to investigate how the glial ion channel CLH-1 controls organismal aging. The key objectives are to establish the function of glial CLH-1 in influencing aging and to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $141,890 to the University of Arkansas to examine the role of the MYC gene in regulating skeletal muscle function, metabolism, and age-related decline. The primary objectives are to: 1) analyze functional, bioenergetic, and cellular changes in skeletal muscle with pulsatile MYC induction and exercise across the lifespan; 2) perform single-cell RNA sequencing and DNA methylation analyses in...