Project Grant R01AG085712

Award Date 8/1/24
Completion Date 7/31/29
Dollars Obligated $737K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Maryland, USA
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This federal Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) provides $134,000 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct a pilot study on a digital cognitive behavioral therapy for insomnia (DCBT-I) intervention for older adults undergoing elective orthopedic surgery. The key objectives are to establish the feasibility of the DCBT-I protocol in this patient population and examine its effects...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $636,957 to Mayo Clinic to conduct a 5-year clinical trial investigating the effects of prescription opioids on brain structure and cognition in older adults with chronic pain. The primary objective is to determine if exposure to opioids is associated with changes in white matter integrity and global cognitive function. The study will randomize 200 participants with chronic osteoarthritis pain...
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This $676,000 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to study the impact of the 2016 CDC opioid prescribing guidelines on disparities in opioid utilization among older adults with opioid-responsive pain conditions. The research will focus on three subgroups of older adults at high risk of pain undertreatment: those with Alzheimer's and related dementias, racial/ethnic minoritized individuals, and those experiencing socioeconomic...
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This federal Project Grant award, valued at $736,503.00 and issued by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to evaluate the effects of combining cognitive-behavioral therapy for insomnia (CBTI) with morning bright light treatment (MBLT) in preventing chronic post-surgical pain (CPSP) and reducing opioid use among older adults undergoing total knee arthroplasty.

The prime awardee, The Johns Hopkins University, will conduct a randomized controlled trial to compare the impacts of CBTI+placebo, CBTI+MBLT, and education+placebo on CPSP, opioid use, insomnia, circadian rhythms, and mood across the perioperative period. The University of Michigan has been awarded a subaward to contribute to this research project. The findings from this comprehensive study are expected to provide critical insights into leveraging non-pharmacological interventions to improve post-surgical outcomes and reduce opioid exposure in the growing older adult population undergoing knee replacement procedures.

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