This $4,361,625 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a collaborative research initiative led by Washington University in St. Louis to investigate the molecular mechanisms underlying cerebral small vessel disease (CSVD) and its vascular contributions to dementia (VCID). The project leverages three key resources: a large collection of cerebrospinal fluid samples, human brain tissue specimens, and advanced neuroimaging...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Wisconsin-Madison is focused on elucidating the role of cerebrovascular disease (CVD) pathways in cognitive decline associated with Alzheimer's disease (AD). The $640,906 award, running from June 1, 2025 to March 31, 2030, will leverage advanced neuroimaging techniques to characterize the impact of vascular disease processes, including vascular stiffness and decreased flow...
The University of Southern California (USC) was awarded a $4,975,336 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to develop advanced magnetic resonance imaging (MRI) techniques for mapping and quantifying cerebral small vessels as imaging biomarkers of vascular cognitive impairment and dementia (VCID). The project aims to optimize acquisition protocols and analysis pipelines for black-blood and arterial spin labeling MRI at 3 Tesla to comprehensively...
This $654,910 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) will fund a study by Rush University Medical Center to identify molecular mechanisms underlying the contribution of cerebrovascular disease (CVD) pathologies to Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRD) in older adults. The key objectives are to: 1) measure RNA transcription levels and proteins in deep frontal white matter to identify...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $834,094 to The University of Texas Southwestern Medical Center to conduct research on post-stroke cognitive impairment and dementia (PSCID). The key objectives are to determine the incidence and prevalence of PSCID, identify associated risk factors, and explore potential pharmacological approaches for prevention. The research will leverage nationwide stroke registry and Medicare data to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $654,238 to The University of Texas Health Science Center at San Antonio to investigate the role of senescent cells in brain aging and Alzheimer's disease and related dementias (ADRD). The study aims to: 1) Identify molecular changes in the microenvironment of senescent neurons compared to healthy neurons, 2) Examine the specific role of senescent neurons in neuronal death in brain aging and...
This $1,493,584 project grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to identify novel genetic risk factors for Alzheimer's disease and related brain imaging phenotypes. The University of Texas Health Science Center at Houston (UTHealth) is the primary awardee and will develop statistical and computational methods for efficient genetic association mapping using identical-by-descent (IBD) segments. UTHealth will apply these IBD mapping...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $254,250 to New York University (NYU) School of Medicine to develop a multi-scale model of brain aging and Alzheimer's disease (AD). The project will leverage advanced diffusion MRI (dMRI) and mesoscopic MRI (meso-MRI) techniques to analyze brain microstructural changes across the lifespan and along the AD continuum. The goal is to create a brain microstructure age framework that can...
This federal Project Grant award, identified as R01AG087513, was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The $622,401 grant aims to elucidate the causal sequence of brain biomarker changes leading to Alzheimer's disease and related dementias (ADRD), as well as identify modifiable lifestyle factors that may resist or delay disease onset. The project has three key objectives: 1) Develop novel deep learning models to predict cerebrospinal...
This federal Project Grant award of $2,919,399 from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research on the relationship between cerebral tau deposition, cerebrovascular disease, and cognitive decline in Mexican American older adults. The award will fund the development and validation of tau PET imaging and cerebrovascular disease measures, as well as the examination of their associations with longitudinal cognitive decline. The project will also...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $790,491 to The University of Texas Health Science Center at San Antonio (UTHSCSA) to develop and validate novel, computerized methods for quantifying cerebral small vessel disease (SVD) markers from brain MRI scans. The goal is to integrate these SVD biomarkers into Alzheimer's Disease Research Center (ADRC) cohorts to better assess the contribution of vascular pathology to Alzheimer's disease and related dementias. UTHSCSA will collaborate with researchers at Wake Forest University Health Sciences on statistical analysis and model validation to produce a harmonized dataset of SVD markers across diverse ADRC populations. This foundational work aims to create a critical resource for understanding vascular contributions to cognitive impairment in Alzheimer's research studies.