This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), provides $2,919,399 to The University of Texas Health Science Center at San Antonio (UTHSCSA) to conduct research on cerebral tau deposition and comorbid cerebrovascular disease across the Alzheimer's disease continuum in Mexican Americans.
The key products and services to be delivered under this 5-year award include:
- Developing and validating traditional and novel tau PET imaging and cerebrovascular disease measures in a longitudinal cohort of 500 Mexican American older adults
- Assessing the diagnostic accuracy of the tau PET indices and their associations with longitudinal cognitive decline
- Evaluating the interactive effects of tau and cerebrovascular disease burden on cognition, and employing causal inference modeling to elucidate pathways linking social determinants of health and modifiable cardiovascular risk factors with Alzheimer's and related dementias
- Validating the imaging and plasma biomarker findings in an independent sample of 1,000 Hispanic and 1,000 non-Hispanic white older adults
The University of Houston System and Cedars-Sinai Medical Center are serving as sub-awardees, providing complementary expertise in neuropsychology, epidemiology, and health disparities research to support the project.
Generated 3/18/25, 3:32 AM