Project Grant R01AG080052

Award Date 9/15/24
Completion Date 5/31/29
Dollars Obligated $768K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Newark, DE 19716, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $640,906 to the University of Wisconsin - Madison to elucidate cerebrovascular disease pathways contributing to cognitive decline. The 5-year project, effective June 1, 2025, aims to leverage advanced neuroimaging techniques to characterize dynamic vascular and hemodynamic factors, such as intracranial vascular stiffness and neurovascular flow tone, that may impact brain tissue integrity and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) aims to develop advanced MRI techniques to directly assess cerebral microvascular pulsatility on widely available 3T MRI systems. The $4,692,540 award to Northwestern University will fund research to evaluate cerebral microvascular pulsatility as a potential biomarker for cerebral small vessel disease (CSVD), which is a major contributor to strokes and dementia. The project, running from August 2024 to...
This federal Project Grant award, totaling $715,801.00, was awarded by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program. The grant will support research at Duke University to elucidate the contributions of endothelial cells and perivascular macrophages to surgery-induced neuroinflammation, blood-brain barrier disruption, and delirium-like behavior in aging and hypertension. The research aims to ascertain the causal role of these targets as key contributors...
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $768,427 supports a 3-year longitudinal study to determine the relationship between midlife vascular risk factors, cerebrovascular pulsatility, brain tissue integrity, and cognitive aging. The primary objectives are to: 1) determine the mechanisms leading to age-related increases in cerebrovascular pulsatility, 2) assess the spatial and temporal correlation between changes in cerebrovascular pulsatility and brain tissue viscoelasticity, and 3) evaluate whether cerebrovascular pulsatility mediates the loss of cognitive performance through disruption of hippocampal function. The award was granted to the University of Delaware, a private research university with extensive experience conducting health-related research projects for federal agencies. This study aims to identify early mechanisms by which vascular aging contributes to the loss of brain tissue integrity and cognitive decline, with the goal of informing new interventions to prevent age-related cognitive impairment.

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