Project Grant R01AA032534
- Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a $161,000 Project Grant under the Alcohol Research Programs (CFDA 93.273) effective September 15, 2025, with a completion date of August 31, 2027. This grant funds mechanistic research investigating the metabolic basis of sarcopenia (skeletal muscle loss) in alcohol-related liver disease (ALD). The research employs...
- The National Institute on Alcohol Abuse and Alcoholism awarded The University of Texas Health Science Center at San Antonio $664,792 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate post-transcriptional mechanisms and cellular senescence in age-related alcoholic liver disease. The research targets dysregulated nutrient sensing as a hallmark of aging that drives hepatic steatosis progression toward cirrhosis and hepatocellular carcinoma. The recipient will...
- The National Institute on Alcohol Abuse and Alcoholism, part of the National Institutes of Health within the Department of Health and Human Services, awarded $682,736 to Beth Israel Deaconess Medical Center, Inc. on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate myeloid-derived suppressor cells (MDSCs) in alcohol-associated steatohepatitis. The award funds research characterizing MDSC phenotypes and immunoregulatory capacity in alcohol-associated hepatitis...
- The National Institute on Alcohol Abuse and Alcoholism awarded Cedars-Sinai Medical Center $1.235 million under the Alcohol Research Programs (CFDA 93.273) on September 10, 2025, to investigate the role of prohibitin 1 (PHB1) in ethanol's sensitizing effect on colorectal liver metastasis. Research will examine how excessive alcohol intake depletes hepatocyte nuclear and cytosolic PHB1, increasing matrix metalloproteinase-7 (MMP-7) expression and rendering the liver susceptible to colorectal...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), a division of the Department of Health and Human Services National Institutes of Health, awarded Yale University $663,419 on August 11, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate liver sinusoidal endothelial cell (LSEC) inflammation in alcohol-associated liver disease. The research addresses mechanisms by which alcohol disrupts LSEC homeostasis through two converging pathways: IL6 trans-signaling mediated...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Trustees of Columbia University in the City of New York $2,359,200 on July 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the regulation of hepatocyte functions by hepatic stellate cells in steatotic liver diseases, including alcohol-associated liver disease, metabolic dysfunction-associated fatty liver disease, and mixed forms. The research characterizes an R-spondin 3-mediated hepatic stellate cell...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Kansas Medical Center Research Institute, Inc. $596,476 on May 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the role of acute phase response signaling in alcohol-associated liver disease resolution. The project, awarded as a Project Grant (R01AA032810), funds research examining how hepatocytes direct a resolution program following alcohol cessation, producing signals that alter liver...
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $456,096 under Project Grant R21AA031889 on September 10, 2025, to explore the role of hepatocyte inflammasome in alcoholic liver disease (AALD). The research investigates how caspase-1, a component of the inflammasome pathway, influences AALD pathophysiology in hepatocytes. The project employs liver-specific genetic deletion models using albumin-cre mice, bulk RNA sequencing, proteomic analysis, and in vitro...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Ohio State University $1,188,981 on September 20, 2025, under the Alcohol Research Programs (CFDA 93.273) to mechanistically characterize JNK2A variants in alcohol-caused heart failure. The research investigates how long-term excessive alcohol consumption drives alcoholic cardiomyopathy through alcohol-activated JNK2 regulation of the SERCA2 calcium pump, moving from adaptive cardiac remodeling to maladaptive suppression of...
- The National Institute on Alcohol Abuse and Alcoholism, part of the Department of Health and Human Services National Institutes of Health, awarded Mayo Clinic $404,352 on September 15, 2025, under the Alcohol Research Programs (CFDA 93.273) to develop machine learning and spatial transcriptomics tools for diagnosis and prognosis of alcohol-associated liver disease (ALD), metabolic dysfunction-associated steatotic liver disease (MASLD), and mixed-etiology metabolic syndrome-associated alcoholic...
The National Institutes of Health National Institute on Alcohol Abuse and Alcoholism awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $353,250 under the Alcohol Research Programs (CFDA 93.273) on September 1, 2026, to investigate mechanisms of skeletal muscle loss in alcohol-associated liver disease. The recipient will conduct research testing the hypothesis that ethanol-induced acetylation stabilizes HIF1A, reducing mitochondrial oxidative function and accelerating post-mitotic senescence with consequent sarcopenia in ALD, using specific aims in murine myotube cell lines and primary models. The work addresses the absence of consistently effective therapies for alcohol-related sarcopenia despite its recognized contribution to morbidity, mortality, and adverse outcomes after liver transplantation. Performance occurs in Cleveland, Ohio, with a period of performance from September 1, 2026, through May 31, 2031. This is a Project Grant, an assistance type supporting projects recommended for approval by the National Advisory Council on Alcohol Abuse and Alcoholism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $353.3k | 8/26/26 |