Project Grant R01AA031805
- This Project Grant award of $123,045.00 from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) supports research on the role of the TRAF3IP2 protein in the development of alcohol-related cardiomyopathy. The project will investigate whether alcohol-induced cardiac fibroblast activation, proinflammatory cytokine expression, and extracellular matrix changes are dependent on TRAF3IP2, and whether deleting the TRAF3IP2 gene prevents alcohol-induced...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $105,132 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Kentucky Research Foundation. The grant, titled "Uncovering the Functional and Mechanistic Dysregulation of Monocytes After Abstinence and Post-Abstinence Drinking," will leverage a rhesus macaque model to investigate the persistent functional, transcriptional, and epigenetic changes in peripheral monocytes induced by...
- The University of California Irvine was awarded a $412,125 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The grant funds a research project to comprehensively determine how alcohol consumption alters the metabolism of critical organs, which can contribute to alcohol-induced organ damage. The project will employ arteriovenous metabolomics to quantitatively measure the dynamic metabolic...
- This $177,736 Project Grant award was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to Beth Israel Deaconess Medical Center, Inc. (Bidmc) located in Massachusetts. The project aims to investigate the role of hepatokines, predominantly hepatocyte-secreted proteins, in the pathogenesis of alcohol-associated liver disease and alcohol-associated hepatitis. Specifically, the research will explore the involvement of the...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $550,417 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Texas at Austin. The grant, effective September 1, 2025 through May 31, 2030, supports research to investigate how heavy alcohol exposure in aging individuals leads to impaired microglia function, neurodegeneration, and cognitive deficits. The study aims to determine whether dysregulated neuroimmune and microglia responses are...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $161,000.00 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The award supports research to investigate the metabolic basis of sarcopenia, or loss of muscle mass, in alcohol-related liver disease (ALD). The key research objectives include using multi-omics analyses to identify global skeletal muscle...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $249,000.00 to East Tennessee State University to characterize acetaldehyde-protein adducts and their effects on lymphocyte function in alcohol-associated liver disease. The research aims to investigate how the ethanol metabolite acetaldehyde forms adducts on proteins, particularly albumin, and how this modulates the pathogenesis of...
- This federal Project Grant award of $396,643 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) supports research to elucidate the mechanisms underlying stress-potentiated ethanol drinking. The project aims to investigate the role of the histone methyltransferase G9a and its effects on dynorphin-positive neurons in the nucleus accumbens to regulate this behavior. Key objectives include testing the hypothesis that G9a's effects on...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $404,250 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Tennessee Health Science Center. The grant, awarded on September 23, 2025 with an ultimate completion date of August 31, 2027, supports research to explore the role of margaric acid in alcohol-associated liver diseases (AALD). The project aims to determine if margaric acid supplementation can attenuate alcohol-induced gut and liver...
- The Project Grant award of $657,156.00 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), supports research to examine the role of BK channels in alcohol-induced dysmyelination. The project aims to investigate the structural and functional correlates of myelin protein changes in a mouse model of alcohol use disorder, focusing on the effects of alcohol on oligodendrogenesis and pre-existing myelin. Key objectives include using...
This is a Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to The Ohio State University. The $593,803 grant, awarded on September 20, 2025, supports a research project titled "Mechanistic Characterization of JNK2A Variants in Alcohol-Caused Heart Failure." The project aims to investigate the role of the JNK2 protein and its variants in the development of alcoholic cardiomyopathy, a leading cause of non-ischemic dilated cardiomyopathy and heart failure associated with long-term excessive alcohol consumption. The research will explore how JNK2 interacts with and regulates the SERCA2 calcium pump, which is essential for proper cardiac function, in the context of alcohol-induced cardiac remodeling. The ultimate goal is to advance the understanding of the underlying mechanisms driving alcohol-related heart failure in order to inform the development of more effective prevention and treatment strategies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $593.8k | 9/19/25 |