Project Grant R01AA032143
- The National Institute on Alcohol Abuse and Alcoholism awarded The University of Texas Southwestern Medical Center $478,080 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate ferroptosis propagation in advanced alcoholic liver disease. The project, titled "Combating Advanced Alcoholic Liver Disease by Blocking Intercellular Signaling That Propagates Ferroptosis," addresses a cell death pathway triggered by lipid peroxide accumulation that spreads...
- The National Institute on Alcohol Abuse and Alcoholism, part of the National Institutes of Health within the Department of Health and Human Services, awarded $682,736 to Beth Israel Deaconess Medical Center, Inc. on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate myeloid-derived suppressor cells (MDSCs) in alcohol-associated steatohepatitis. The award funds research characterizing MDSC phenotypes and immunoregulatory capacity in alcohol-associated hepatitis...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), a division of the Department of Health and Human Services National Institutes of Health, awarded Yale University $663,419 on August 11, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate liver sinusoidal endothelial cell (LSEC) inflammation in alcohol-associated liver disease. The research addresses mechanisms by which alcohol disrupts LSEC homeostasis through two converging pathways: IL6 trans-signaling mediated...
- The National Institute on Alcohol Abuse and Alcoholism awarded The University of Texas Southwestern Medical Center $702,746 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate epigenetic regulation of endogenous retroviruses and alcohol-associated liver disease. The research will define mechanisms by which alcohol metabolism induces endogenous retrovirus (ERV) reactivation, reverse transcription, and innate immune activation, focusing on metabolic and...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Texas Health Science Center at Houston $1.772 million on September 15, 2025, under the Alcohol Research Programs (CFDA 93.273) to develop and validate a microbial-based platform for assessing alcohol-related organ damage in alcohol use disorders. The recipient will develop a comprehensive web-based knowledge module integrating microbiota, metabolites, and host pathways to map microbial signatures and mechanisms...
- The National Institute on Alcohol Abuse and Alcoholism awarded Texas A&M University System Health Science Center $635,002 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate cholinergic modulation of striatal circuits in alcohol use disorder. The project examines how chronic alcohol intake affects acetylcholine signaling in the dorsomedial striatum, focusing on the interaction between direct-pathway medium spiny neurons and cholinergic interneurons. Research...
- The National Institutes of Health National Institute on Alcohol Abuse and Alcoholism awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $353,250 under the Alcohol Research Programs (CFDA 93.273) on September 1, 2026, to investigate mechanisms of skeletal muscle loss in alcohol-associated liver disease. The recipient will conduct research testing the hypothesis that ethanol-induced acetylation stabilizes HIF1A, reducing mitochondrial oxidative function and...
- The National Institute on Alcohol Abuse and Alcoholism awarded Beth Israel Deaconess Medical Center, Inc. $177,736 on August 17, 2026, under the Alcohol Research Programs (CFDA 93.273) to support a postdoctoral researcher's career development in understanding the role of neutrophil extracellular traps (NETs) in alcohol-induced acute-on-chronic liver failure. The award funds a two-year mentored research program spanning August 17, 2026, through July 31, 2028, based in Boston, Massachusetts. The...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Trustees of Columbia University in the City of New York $2,359,200 on July 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the regulation of hepatocyte functions by hepatic stellate cells in steatotic liver diseases, including alcohol-associated liver disease, metabolic dysfunction-associated fatty liver disease, and mixed forms. The research characterizes an R-spondin 3-mediated hepatic stellate cell...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Kansas Medical Center Research Institute, Inc. $596,476 on May 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the role of acute phase response signaling in alcohol-associated liver disease resolution. The project, awarded as a Project Grant (R01AA032810), funds research examining how hepatocytes direct a resolution program following alcohol cessation, producing signals that alter liver...
The National Institute on Alcohol Abuse and Alcoholism awarded The University of Texas Health Science Center at San Antonio $664,792 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate post-transcriptional mechanisms and cellular senescence in age-related alcoholic liver disease. The research targets dysregulated nutrient sensing as a hallmark of aging that drives hepatic steatosis progression toward cirrhosis and hepatocellular carcinoma. The recipient will elucidate post-transcriptional mechanisms by which age-associated hepatocyte SIRT1 defects induce lipogenic reprogramming and exacerbate alcohol-related pathology, examine the role of cellular senescence and CD38 (an NAD+ degradation regulator) in age-related liver disease, and evaluate CD38 as a therapeutic target. Performance occurs in San Antonio, Texas, with a period of performance from September 1, 2026, through May 31, 2031. The award is structured as a project grant, the standard assistance type for NIH investigator-initiated research under the Alcohol Research Programs, which supports fundamental research applicable to improved treatment and prevention of alcoholism and alcohol-related disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $664.8k | 8/25/26 |