Project Grant K08AA032553
Award Date 9/15/25
Completion Date 8/31/30
Dollars Obligated $202K
Federal Agency
Awardee
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Minnesota, USA
Similar Awards
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) provides $440,566 to Yale University to advance the treatment of alcohol-associated liver disease (ALD). The primary objective is to uncover therapeutic targets and develop effective ALD treatments, with a focus on the methyltransferase-like (METTL) protein family, notably METTL7A, which is highly expressed in ALD patients. The research utilizes cutting-edge technology...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $161,000.00 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The award supports research to investigate the metabolic basis of sarcopenia, or loss of muscle mass, in alcohol-related liver disease (ALD). The key research objectives include using multi-omics analyses to identify global skeletal muscle...
- This Project Grant award of $1,982,628.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to develop advanced methods for detecting liver fibrosis and creating a predictive diagnostic model for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in primary care settings. The project aims to improve identification of...
- This Project Grant award of $639,177.00 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support research to investigate the role of hepatic FOXA3 in the development and progression of alcohol-associated liver disease (ALD). The University of Arizona will conduct this research project to gain a better understanding of the mechanisms underlying the pathogenesis of ALD, which is the most prevalent...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $253,383 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Yale University to explore the role of the hepatocyte inflammasome in alcoholic liver disease (ALD). This research aims to investigate the liver-specific effects of the inflammasome, a key mediator of inflammation, in hepatocytes - the predominant liver cell type and a driver of ALD pathophysiology. The project will use mouse models to evaluate...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) provides $734,283 to Mayo Clinic to explore the relationships between circulating neuroactive steroid levels and alcohol use disorder (AUD), as well as AUD-related phenotypes. The project aims to measure the serum levels of allopregnanolone, its precursors, and isomers using gas chromatography coupled with mass spectrometry. This neuroactive...
- This $177,736 Project Grant award was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to Beth Israel Deaconess Medical Center, Inc. (Bidmc) located in Massachusetts. The project aims to investigate the role of hepatokines, predominantly hepatocyte-secreted proteins, in the pathogenesis of alcohol-associated liver disease and alcohol-associated hepatitis. Specifically, the research will explore the involvement of the...
- This federal Project Grant award of $539,237 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), supports research on a novel deep brain stimulation (DBS) approach that combines spike-timing dependent plasticity (STDP) to selectively modulate maladaptive neural plasticity associated with alcohol addiction and other neurological/psychiatric disorders. The project aims to apply precisely-timed STDP-DBS stimulation in two brain...
- This federal Project Grant award of $701,051 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273). The grant supports research to investigate the phenotypes and functions of distinct neutrophil populations in patients with severe alcohol-associated hepatitis (AH). Key objectives include: 1) Characterizing the transcriptomic profiles and functional roles of neutrophil subsets in AH using single-cell RNA sequencing; 2)...
- The federal Project Grant award titled "Role of Functional Iron Deficiency in Alcohol-Associated Liver Disease" is funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273). The $390,480 award, effective from September 10, 2025 to August 31, 2027, will support research at Emory University to investigate the molecular mechanisms underlying alcohol-associated mitochondrial dysfunction and its role in the progression of...