The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $146,000 Project Grant under its Alcohol Research Programs (CFDA 93.273) to Louisiana State University Health Sciences Center-Shreveport. This 2-year grant will fund research to examine the impact of chronic alcohol use on acetylcholine signaling in the brain of rhesus macaques. The key objectives are to: 1) refine and validate techniques for measuring acetylcholine release in mouse brain slices, and then 2) use these...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $537,587 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The University of Texas Southwestern Medical Center to conduct research on the metabolic consequences of liver inflammation on alcohol consumption and alcohol-associated liver disease (ALD). The key objectives are to identify the mechanisms by which the transcription factor IRF3 suppresses the expression and secretion of the metabolic regulator...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $438,375 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Cedars-Sinai Medical Center to establish a human liver-on-a-chip model for studying alcohol-associated liver disease (ALD). The 2-year project, starting September 2023, aims to investigate the roles of liver sinusoidal endothelial cells and acetaldehyde metabolism in regulating ethanol-induced liver damage as well as the contribution of fibrotic...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $235,750 Project Grant (CFDA 93.273 - Alcohol Research Programs) to Rhode Island Hospital to study the detection and monitoring of alcohol-related white matter brain pathology. The project aims to leverage the hospital's existing bank of human alcohol use disorder (AUD) and control serum samples to characterize the effects of ethanol and different treatments on the expression of oligodendrocyte/myelin proteins,...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $143,784 Project Grant (CFDA 93.273 - Alcohol Research Programs) to Louisiana State University Health Sciences Center New Orleans on July 30, 2024. The grant will support research to investigate the effects of adolescent opioid exposure on alcohol-induced hyperalgesia (increased pain sensitivity) in adult mice. The research aims to test the hypothesis that exposure to opioids during adolescence increases the magnitude of...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $151,869 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Iowa. The grant, awarded on May 1, 2025, supports research to understand the impact of chronic alcohol exposure on metabolic function and tau pathology in Alzheimer's disease (AD) progression. The key objectives of the project are to: 1) assess the influence of chronic ethanol exposure on metabolic function and tau pathology in the...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $220,656 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center (UNMC) division. The grant will fund research to investigate the effects of ethanol metabolism on the sorting of non-isgylated HIV proteins to hepatocyte-derived exosomes, and how these exosomes impact the pro-fibrotic activation of hepatic stellate...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) program, provides $374,598 to the University of Louisville to investigate the impact of alcohol consumption on RNA modifications and their potential contribution to the development and progression of alcohol-associated liver disease (ALD). The key objectives of this 2-year project are to: 1) Map the chemical modifications on RNAs isolated from...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development of novel 3D human brain circuits to investigate the role of microglia in alcohol use disorder (AUD) and Alzheimer's disease (AD) pathology. The $223,531 award to the University of North Carolina at Chapel Hill will fund research to elucidate how alcohol-induced changes in microglial metabolism...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, is focused on investigating the effects of chronic alcohol exposure on the biogenesis, distribution, and RNA content of astrocyte-derived exosomes. The $187,031 award will fund a 2-year research project to: 1) Develop an in vivo model to track astrocyte-derived exosomes and profile their RNA content, and 2) Determine how chronic...