Project Grant K99AA032034
Award Date
5/1/25
Completion Date
4/30/27
Dollars Obligated
$152K
Federal Agency
National Institute on Alcohol Abuse and Alcoholism
Federal Grant Program
93.273
Assistance Type
Project Grant
Place of Performance
Iowa City, IA 52242, USA
Similar Awards
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to determine the role of microglia in alcohol use disorder (AUD) and Alzheimer's disease (AD) pathology. The $223,531 award will fund the development of novel 3D reciprocal brain circuits using human iPSC-derived neurons and microglia to study how alcohol-induced changes in microglial metabolism and function impact neuronal...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), will examine alcohol consumption as a modifiable risk factor for Alzheimer's disease and related dementias (ADRD). The $468,534 grant, awarded on September 23, 2024, will support an exploratory/developmental study using data from over 32,000 male and female twins from the Swedish Twin Registry. The research aims to delineate the relationship between midlife alcohol...
This $119,600 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, aims to identify and understand the mechanisms by which aging and alcohol consumption cooperatively contribute to the overall decline in liver function and the subsequent development of alcohol-associated liver disease (ALD). The award recipient, the University of Kansas Medical Center Research Institute, Inc. (KUMCRI),...
This federal Project Grant award for $594,784.00, awarded on July 15, 2024 by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), will fund a multi-omic study of alcohol use disorder (AUD) in the human brain. The research team from Yale University will perform postmortem analyses of brain tissue samples from 341 subjects, including 100 with AUD, 132 with major depressive disorder, and 109 neurotypical controls. The study aims to...
This Project Grant award in the amount of $404,508.00 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The award aims to examine interleukin-1β (IL-1β) synaptic regulation and its role in cognitive impairment during early withdrawal and protracted abstinence from chronic alcohol exposure in male and female mice. The overarching goal is to determine the neuroimmune mechanisms by which chronic...
This federal Project Grant award, valued at $517,248.00, was awarded on July 8, 2024 by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program. The grant supports research to explore the mechanisms by which acute and chronic ethanol exposure regulate a specific pathway involving norepinephrine, astrocytes, and dopamine neurons in the ventral periaqueductal gray region of the brain. This research aims to understand...
This $517,379 federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, supports research to investigate the role of KDM5 demethylases in alcohol-associated liver disease (ALD) development and resolution. The project aims to determine how these epigenetic regulators in hepatocytes mediate cellular crosstalk that promotes ALD progression and fibrosis, as well as define the mechanisms by...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $438,375 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Cedars-Sinai Medical Center to establish a human liver-on-a-chip model for studying alcohol-associated liver disease (ALD). The 2-year project, starting September 2023, aims to investigate the roles of liver sinusoidal endothelial cells and acetaldehyde metabolism in regulating ethanol-induced liver damage as well as the contribution of fibrotic...
This $328,500 federal Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to investigate the role of lysophosphatidic acid (LPA) signaling in alcohol-induced blood-brain barrier (BBB) disruption and neuroinflammation. The proposed study aims to assess the effects of heavy alcohol consumption on mitochondrial function, redox balance, and endothelial activation in the...
This $479,164 federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to identify genetic factors that influence behavioral outcomes in individuals with prenatal alcohol exposure (PAE). The key objectives are to: 1) Explore additional choline-related genetic polymorphisms that may modulate cognition and behavior in those with PAE, and 2) Directly test the influence of the ALDH1L1 gene,...