Project Grant R00HG013429
- Federal Grant Award Summary The University of Virginia received a $1,092,610 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 15, 2026, with completion targeted for February 28, 2030. The award funds development of an Impedance-Activated Recognition, Tracking, and Sorting (IARTS) system designed to enable near-real-time, label-free identification and isolation of phenotypically...
- Federal Grant Award Summary The University of Virginia received a $444,125 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026 through February 28, 2031. This award supports fundamental research investigating the mechanisms of genome integrity maintenance, specifically focusing on break-induced replication (BIR) at repetitive DNA sequences and telomere maintenance in...
- Federal Grant Award Summary The National Human Genome Research Institute (NHGRI) awarded a $249,000 Project Grant to the Regents of the University of California at Riverside on September 23, 2025, under the Human Genome Research program (CFDA 93.172). This award supports the development and application of laser particles (LPs)-based technology for spatiotemporal and dynamic single-cell multiomics research. The project will create a novel "dual-barcoding" cell tracking system...
- Federal Project Grant Award Summary The University of North Carolina at Chapel Hill received a $249,000 Project Grant from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded September 23, 2025, with a completion date of August 31, 2028. This award supports a two-year training program designed to develop machine learning integration algorithms for predicting undercharacterized genomic and proteomic data in single-cell analysis....
- Federal Project Grant Award Summary The University of Virginia received a $395,698 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded February 15, 2026, with a completion date of January 31, 2031. This award supports fundamental basic research investigating how the structural complexity and spatial organization of stem cell niches enable their regulatory function during development and...
- Federal Grant Award Summary The University of Virginia received a $425,145 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026, through February 28, 2031. This award supports the development of integrated microscopy and image processing technologies to enable non-invasive, long-term three-dimensional (3D) fluorescence imaging and single-cell morphometry of...
- Federal Grant Award Summary The National Human Genome Research Institute (NHGRI) awarded Fred Hutchinson Cancer Center a $2.409 million Project Grant (CFDA 93.172: Human Genome Research) on September 19, 2025, to develop an experimental-data-based in-silico data generation platform for improving single-cell and spatial omics analysis. The project, extending through August 31, 2029, will deliver three primary products: (1) statistical methods and tools for generating in-silico negative controls...
- Federal Grant Award Summary The University of Georgia Research Foundation, Inc. received a $248,943.00 Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), effective May 11, 2026, with a completion date of February 28, 2029. This award funds research investigating the genomic basis of variation in transcriptional responses to pathogens across primate species. The research will characterize how genetic...
- Federal Project Grant Award Summary Duke University's Office of Research Administration is awarded $444,125 through the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) to develop advanced computational methods and bioinformatics software for analyzing spatial transcriptomics data. The project, initiated May 1, 2026 and concluding February 28, 2031, will deliver three primary product categories: (1) machine learning methods...
- Federal Grant Award Summary The University of Virginia, under funding from the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences through the Biological Sciences program (CFDA 47.074), received a $741,544 Project Grant awarded August 1, 2025, with completion targeted for July 31, 2028. Led by Dr. Ahmad Jomaa at the University of Virginia in collaboration with Dr. Simone Mattei at the EMBL Imaging Center in Germany, this research project investigates ribosome...
The University of Virginia received a $249,000 Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), effective May 11, 2026, through February 28, 2029. The award supports the development of computational frameworks to model how external cell signaling impacts transcriptional changes in cells using spatial transcriptomics and single-cell multiome data. The research addresses a critical gap in identifying cell-cell interactions (CCIs)—the crucial biological communications that drive processes including cell differentiation, inflammation, wound repair, and cancer development—which have historically relied on low-throughput manual methods. The funded project will deliver three primary computational tools: (1) an improved version of BayesPrism to enhance deconvolution of cell type fractions and gene expression from bulk RNA sequencing and spatial transcriptomics data; (2) a novel computational method for jointly modeling the relationship between CCIs and downstream gene expression to provide interpretable biological insights; and (3) an extension incorporating epigenetic information from single-cell multiomics data. These tools are designed to overcome current methodological limitations, including robustness challenges when using multiple single-cell RNA sequencing references, the reliance on transcription levels that may not reflect active protein levels, and deficiencies in capturing transcription factor activity. The research will be conducted at the University of Virginia's Charlottesville, Virginia location.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 5/14/26 |