Project Grant R00HG013129
- The National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) awarded a $550,810 Project Grant to the University of California, Irvine (UCI) to develop an innovative AI-assisted Laser Capture Microdissection (AI-LCM) approach for spatial transcriptomics. This method aims to provide high-throughput, comprehensive spatial transcriptomics analysis with single-cell resolution and genome-wide coverage. The key products/services include: Optimizing in situ generation and...
- This federal Project Grant award of $1,350,896, awarded on January 1, 2025 by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), supports the development of a multimodal massively parallel reporter assay (MPRA) platform to study regulatory sequence function. The overarching goal is to create tools that can elucidate the mechanisms and grammar by which regulatory elements in the genome encode interactions between chromatin, regulatory...
- This $2,409,233 federal Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports the development of a suite of advanced statistical tools and user-friendly software to enhance the accuracy and reproducibility of single-cell and spatial omics data analysis. The key products and services to be delivered under this 4-year award include: Statistical methods to generate in silico data for use as negative controls and pseudo-replicates of...
- This $993,446 Project Grant award from the National Human Genome Research Institute (CFDA 93.172 Human Genome Research) supports the development of statistical and machine learning approaches to decode the regulatory activity underlying disease variants, link variants to genes in relevant cell types, and identify disease-critical cooperative programs of genes and genomic elements. The goal is to produce computational tools and workflows that can identify and rank functionally disease-critical...
- This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), awarded a $396,170 project grant to Syntaxisbio Inc. on September 17, 2025. The grant supports the development of an innovative technology using genetic PUFs (Physical Unclonable Functions) to precisely quantify the age and division/passage history of cell lines. This technology aims to address the critical challenge of reliable cell line identification and validation in...
- This federal Project Grant award of $135,206 from the National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), supports the development of two novel single-cell functional genomic technologies to investigate the causal relationship between DNA methylation changes and gene expression in human diseases. The award recipient, The Regents of the University of California, San Francisco (UCSF), aims to: 1) Develop a single-cell version of...
- The National Human Genome Research Institute (NHGRI) awarded a $291,232 Project Grant to Micropure Genomics Inc. on September 17, 2025 under the Human Genome Research Federal Grant Program (CFDA 93.172). The project aims to develop an automated, bead-less, and gel-less microfluidic size selection approach to simplify workflows, reduce costs, and enhance the performance of long-read DNA sequencing technologies such as PacBio and Oxford Nanopore. The proposed innovation, called mPREP, leverages...
- This federal Project Grant award for $390,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of new tools for high-throughput characterization of extracellular RNA, DNA, and vesicles in bodily fluids. The primary objectives are to: 1) develop methods to reliably control for technical variability, RNA degradation, and complexity in cell-free RNA (cfRNA) analysis, including...
- The National Human Genome Research Institute (NHGRI) awarded a $400,000 Project Grant (CFDA 93.172 - Human Genome Research) to the University of Washington to develop new single-cell multi-omic technologies for studying the relationship between three-dimensional genome organization and gene expression. Specifically, the grant will fund the development of CARE-Seq, a novel method to jointly measure whole-genome chromatin interactions and gene expression in the same single cells from complex...
This federal Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172) provides $249,000.00 to the Regents of the University of California at Riverside to develop a novel "dual-barcoding" technology that utilizes laser particles with unique optical barcodes. This technology aims to enable the collection of live information on cells and connect that data to detailed omics information at the single-cell resolution. The key products or services to be delivered include: The project period runs from September 23, 2025 to August 31, 2028, with the goal of advancing understanding of human genetics and developing innovative genomic technologies through this cutting-edge single-cell research approach.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 9/24/25 |