Project Grant R01EY038524
- Federal Grant Award Summary The University of North Texas Health Science Center at Fort Worth received a $249,000 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 15, 2026, with completion targeted for March 31, 2029. This research initiative focuses on identifying therapeutic interventions to prevent cell death in human corneal stromal cells as a non-surgical treatment approach for keratoconus, a progressive corneal disorder...
- Federal Grant Award Summary New York University School of Medicine received a $546,439 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 15, 2026, with completion anticipated by March 31, 2030. The award funds research to develop corneal stromal keratocyte modeling from human cornea organoids (HCOs) as a potential therapy for corneal scarring and keratoconus-related blindness. The research leverages HCOs generated from induced...
- Federal Grant Award Summary New York University School of Medicine received a $285,498 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) effective September 30, 2025, with an ultimate completion date of August 31, 2027. This research grant funds fundamental scientific investigation into corneal lens development mechanisms using Drosophila (fruit fly) as a model organism to better understand human corneal curvature disorders including...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant totaling $900,600 to The Regents of the University of California, San Francisco, with an award date of September 1, 2025, and completion date of August 31, 2027, under the Vision Research program (CFDA 93.867). This award funds research directed at understanding corneal limbal stem cells (LSCs) during wound healing processes. The project addresses the significant clinical need for restorative treatments for...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $421,136 Project Grant to the University of Maryland, College Park, effective August 1, 2025, through July 31, 2027, under the Vision Research program (CFDA 93.867). This award supports research into advanced wavefront shaping techniques designed to enable high-resolution fundus imaging in patients with ocular opacities—conditions affecting the cornea and lens that currently prevent effective posterior segment eye...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $384,364 to the University of Nebraska Medical Center under the Vision Research program (CFDA 93.867) beginning September 1, 2025, through May 31, 2030. This project grant funds research to investigate the molecular mechanisms underlying age-related cataracts (ARC) by examining the dysregulation of the BMAL1 (Brain and Muscle ARNT-Like Protein 1) clock protein and NRF2 (NFE2-Related Factor 2) antioxidant pathways in the...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant of $497,740 to the University of Illinois (Chicago, IL) under the Vision Research program (CFDA 93.867), effective April 1, 2026, through March 31, 2031. Under the direction of Principal Investigator Elmira Jalilian, this research project will generate scientific findings and empirical data examining neuro-epithelial interactions in corneal disease and repair, with particular focus on how corneal nerves...
- Federal Project Grant Award Summary Texas A&M University System Health Science Center received a $189,542 Project Grant award from the National Eye Institute (Vision Research program, CFDA 93.867) effective June 1, 2025, with completion targeted for January 31, 2028. The project develops optical coherence tomography (OCT)-guided ultrafast, nonthermal laser microablation technology for non-invasive vitreoretinal surgery. This research evaluates the application of femtosecond lasers as a...
- Federal Grant Award Summary ESK Therapeutics, Inc. received a $330,169 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), with performance commencing September 1, 2025 and concluding August 31, 2026. The award supports the preclinical development and commercialization of CornéaClear, a first-in-class biologic eyedrop therapeutic formulation designed to accelerate corneal wound healing and reduce scarring risk in patients with persistent corneal...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded Northwestern University a $1.62 million Project Grant on September 1, 2025, to develop computational models and diagnostic tools for improving glaucoma treatment outcomes. The three-year project, extending through August 31, 2028, focuses on modeling aqueous humor outflow based on a digital twin of the anterior eye imaged by robotic optical coherence tomography (OCT). The...
The University of North Texas Health Science Center at Fort Worth received a $402,439 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) beginning April 1, 2026 and concluding March 31, 2029. This award funds the development and clinical evaluation of a novel personalized contact lens designed to enable collagen cross-linking (CXL) therapy for keratoconus patients with thin corneas. The research team will design and evaluate a UV-absorbing, thickness-controlled, riboflavin-loaded contact lens to address current limitations of standard CXL treatment, which cannot be safely applied to corneas thinner than 400 micrometers due to endothelial damage risk. The multidisciplinary research team will build upon previously established 3D-printing protocols for biopolymer-based hydrogel contact lenses to create a therapeutic device that provides customized UV attenuation based on individual patient corneal thickness, thereby expanding CXL eligibility to a broader patient population with keratoconus. This project advances the NEI's mission to eliminate vision loss and improve quality of life through innovative vision research by developing a precision medical device that addresses an unmet clinical need in corneal disease treatment. The personalized contact lens approach offers standardized, patient-specific UV protection superior to existing contact lens-assisted CXL methods that rely on variable riboflavin application and fixed protective thickness. The research outputs will include device prototypes, clinical performance data, and therapeutic validation supporting potential clinical translation for keratoconus patients currently ineligible for conventional CXL treatment.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $402.4k | 4/2/26 |