This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), will support research to investigate the molecular, cellular, and transcriptional mechanisms that regulate reactive astrocyte function in the optic nerve head and retina. The research aims to discover new biological pathways that control glial reactivity, with the goal of developing gliotherapeutics for the treatment of glaucoma and other optic neuropathies. The $2,260,440 award...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), will fund research at the University of California, San Francisco (UCSF) to study the neural mechanisms of sensory encoding after photoreceptor degeneration. The $237,588 award, effective June 1, 2025 through December 31, 2027, will leverage the vertical optokinetic reflex, a visual behavior that tracks global motion, to investigate how cone degeneration disrupts noise...
The National Eye Institute (NEI) awarded a $360,100 Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Leland Stanford Junior University (Stanford University) for the project "The Effects of Sleep and ipRGCs on Computations in the Early Visual System". The goal of this 2.5-year project is to investigate how multiplexed photoreceptor inputs, including melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), mediate retinal and...
This Project Grant award, provided by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports research to understand how the retina adapts to photoreceptor loss in retinal degeneration. The $624,230 award to the University of California, Los Angeles (UCLA) spans May 1, 2025 to April 30, 2029. The research aims to document changes in rod photoreceptor function and connectivity as degeneration progresses, as well as investigate plasticity in retinal...
This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) to The Washington University in St. Louis provides $480,376 to support research on the regulation of retinal development by RNA molecules. The project aims to investigate the role of long non-coding RNAs (lncRNAs) in controlling retinal gene regulatory networks, including through interactions with transcription factors. Key research activities include utilizing gain-of-function and loss-of-function...
This Project Grant award from the National Eye Institute (NEI), which is part of the U.S. Department of Health and Human Services, supports research to investigate the transcriptional and developmental basis of a genetic mutation associated with a rare syndrome involving congenital eye and sex development abnormalities. The $125,916 award, granted on March 1, 2025, will fund research at the University of California, Davis to characterize the genetic landscape of the mutation and its effects on...
This Project Grant award of $1,241,223 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research at the University of Pittsburgh to investigate the genetic and epigenetic mechanisms underlying retinal development and vision disorders. The key objectives of this 5-year research project are to: Dissect the molecular, cellular, and genomic effects of genetic mutations on retinal development using mouse models. Elucidate how transcription...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), will provide $475,000 in funding to The Salk Institute for Biological Studies in La Jolla, CA. The goal of this 4-year research project is to characterize the connectivity and functional role of specific neural circuits in the mammalian visual system that transmit information from the retina to the primary visual cortex. The key products and services to be delivered include:...
This Project Grant award, totaling $435,052, was provided by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to the University of Massachusetts Boston. The funding supports research aimed at understanding the molecular mechanisms that control the spatially precise expression patterns of different photoreceptor subtypes required for color vision. The project will investigate how a conserved transcription factor, HMX, interacts with the Hippo...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research to understand the chromatin architectural landscape of retinal development at the single-cell level. The $146,922 award, effective January 30, 2025 through May 31, 2025, aims to capture 3D chromatin interactions of mouse retinal cells at key developmental stages using a single-cell Hi-C (SCHI-C) approach. The research also seeks to identify changes in...