This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $2,260,440 to The Leland Stanford Junior University to investigate the cellular and molecular mechanisms regulating reactive astrocytes in glaucoma and other optic neuropathies. The key objectives are to: 1) establish the role of compartmentalized cAMP signaling and expression of the cell cycle inhibitor p21 in modulating astrocyte reactivity, microglial/macrophage...
The National Eye Institute (NEI) awarded a Project Grant under the Vision Research program (CFDA 93.867) to the University of Washington to study how the retina encodes visual information in natural environments with dynamic changes in light intensity. The $487,862 award, effective September 1, 2024 through May 31, 2029, will support three research aims: 1) determining the role of photoreceptor adaptation in shaping retinal ganglion cell (RGC) responses, 2) probing the contribution of RGC...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) provides $611,546 in funding to the University of California, Berkeley to conduct research on the neural mechanisms underlying sustained visual perception in humans. The key objectives are to: 1) investigate how attention and awareness affect persistent representations of visual stimuli, 2) analyze the structure and information content of field potentials and single neuron spikes in the...
This is a Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), in the amount of $249,000.00. The grant will fund research to investigate the molecular mechanisms that regulate the expression of phototransduction genes in mammalian rod photoreceptors. The research aims to elucidate how transcriptional elongation and mRNA processing are coupled to enhance the efficiency and accuracy of mRNA maturation, and how defects in these...
This Project Grant award of $237,588 from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), will support research on the neural mechanisms of sensory encoding after photoreceptor degeneration. The primary research objectives are to characterize the impact of cone degeneration on noise correlations in direction-selective retinal ganglion cells, and to investigate how these changes in neural computations affect visual behaviors such as the optokinetic reflex. The...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), will provide $475,000 in funding to The Salk Institute for Biological Studies in La Jolla, CA. The goal of this 4-year research project is to characterize the connectivity and functional role of specific neural circuits in the mammalian visual system that transmit information from the retina to the primary visual cortex. The key products and services to be delivered include:...
This $357,056 federal Project Grant award from the National Eye Institute (NEI)'s Vision Research program (CFDA 93.867) supports research to evaluate the functional impact of retinal ganglion cell (RGC) loss during the progression of neurofibromatosis type-1 (NF1) optic glioma, and to examine if transplanted RGCs can integrate into the remaining retinal circuitry. The grant recipient, The Leland Stanford Junior University, will conduct this research in the laboratory of Dr. Jeffrey Goldberg at...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports a comprehensive research study on the development of the human dorsal visual cortex. The $476,451 award, effective March 1, 2025 through February 28, 2030, will be performed by The Trustees of Princeton University. The key objectives of this research are to: 1) Produce developmental atlases mapping the functional organization and structural changes in the dorsal...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $124,205 to The Regents of the University of California, San Francisco (UCSF) to investigate how the hippocampus and primary visual cortex interact to generate coordinated mental simulations during active behavior. The research aims to: Test the generality of the observed coordination between the hippocampus and visual cortex by manipulating external factors. Study the...
This $249,000 federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to elucidate the neurophysiological basis of the brain's "generative model" of the world, as observed through rapid eye movements during REM sleep. The project will investigate the role of the superior colliculus in orchestrating virtual head orienting and rapid eye movements during REM sleep, using advanced neurophysiological techniques...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), is supporting research to investigate the effects of sleep and intrinsically photosensitive retinal ganglion cells (ipRGCs) on computations in the early visual system.
The $360,100 award to The Leland Stanford Junior University aims to: 1) Isolate and measure melanopsin-specific responses in the retina and visual cortex under natural scenes; 2) Record visual cortex responses under natural scenes at different circadian time points and with sleep deprivation; and 3) Use this data to build a predictive computational model of the early visual system that incorporates multiplexed photoreceptor inputs.
The research objectives are to better understand how visual experience is represented in the retina and visual cortex, which could provide insights into vision loss from diseases and disorders affecting the early visual system. The findings may also contribute to improved cortical prosthesis design for restoring lost vision. The project will run from Sep 1, 2024 to Mar 31, 2027.