This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop new methods for incorporating the radioisotope fluorine-18 into complex molecules. The $174,375 award, effective December 5, 2024 through November 30, 2027, will support research at The Johns Hopkins University to explore the use of metal-centered fluorination to...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under CFDA Program 93.286 "Discovery and Applied Research for Technological Innovations to Improve Human Health", supports the development of new radiofluorination methods and prosthetic groups to enable rapid construction of PET tracer analogs. The $122,260 award to the University of North Carolina at Chapel Hill will fund research to develop late-stage direct radiofluorination...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $277,033 to the University of Cincinnati to develop novel approaches for introducing radiolabeled trifluoromethyl groups into PET tracers. The key objectives are to: 1) create a general strategy to transform alkyl halides into alkyl-[11C]CF3 and alkyl-[18F]CF3...
This Project Grant award, valued at $597,766.00, is funded by the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394). The University of Pennsylvania will develop novel methods to image two PET tracers with different molecular targets back-to-back in a single imaging session using a long-axial field-of-view PET scanner, the PennPET Explorer. The key objectives are: Develop protocols to image fluoroglutamine, a research radiotracer of...
This $384,863 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program supports research to develop a novel radiotracer imaging agent for detecting Gram-positive bacterial infections associated with implanted medical devices. The key products and services to be delivered include: In vitro testing of a bivalent radiotracer agent...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $477,129 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. This 4-year grant, which commenced on January 1, 2025, supports the development and evaluation of dextran-coated cerium oxide nanoparticles (DEX-CENP) as a...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $275,773 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to Dropletpharm Inc., a for-profit company. The grant supports Dropletpharm's development of microfluidic technologies to enable low-cost and distributed manufacturing of radiopharmaceuticals for clinical and research applications. Specifically, the project aims to expand...
This federal Project Grant award of $185,171 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) will support research to optimize polymeric chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) agents for prostate cancer detection. The research aims to synthesize and characterize CEST MRI agents with varying charge and...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $502,841 Project Grant under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program to The Regents of the University of California, operating as Lawrence Berkeley National Laboratory (LBNL). The funding will support research and development of a novel detector readout concept for monolithic scintillation detectors that enables direct digitization...
The federal Project Grant award R01EB035144, funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will develop a novel molecular imaging technology that combines positron emission tomography (PET) and ultrasound (US) imaging. The $1,541,316 award, with a period of performance from Sep 1, 2024 to May 31, 2028, aims to create a compact PET device with a...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $505,848.59 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The Trustees of the University of Pennsylvania for the project "METAL-MEDIATED C-H RADIOFLUORINATION FOR RAPID ACCESS TO PET IMAGING AGENTS". The project aims to develop new methods for rapidly synthesizing Fluorine-18 labeled organic molecules for Positron Emission Tomography (PET) imaging agents, with the goal of improving disease detection, treatment, and prevention. Key objectives include optimizing amide C-H radiofluorination protocols, demonstrating feasibility with bioactive PET imaging scaffolds, and assessing the stability of Fluorine-18 labeled amide therapeutics. This award supports the University of Pennsylvania's efforts to advance radiochemistry and organic/organometallic chemistry capabilities for PET imaging applications.