Project Grant R41EB034168

Award Date 9/1/23
Completion Date 8/31/24
Dollars Obligated $276K
Federal Grant Program
93.286
Assistance Type
Project Grant
Place of Performance
Van Nuys, CA 91403, USA
Similar Awards
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $1,149,264 to The University of Texas MD Anderson Cancer Center to develop a rapid, inexpensive microfluidics-based approach for dose-on-demand production of radiopharmaceuticals. The objectives are to: 1) employ a "ship-on-chip" device for isotope...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop new methods for incorporating the radioisotope fluorine-18 into complex molecules. The $174,375 award, effective December 5, 2024 through November 30, 2027, will support research at The Johns Hopkins University to explore the use of metal-centered fluorination to...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under CFDA Program 93.286 "Discovery and Applied Research for Technological Innovations to Improve Human Health", supports the development of new radiofluorination methods and prosthetic groups to enable rapid construction of PET tracer analogs. The $122,260 award to the University of North Carolina at Chapel Hill will fund research to develop late-stage direct radiofluorination...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $505,848.59 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The Trustees of the University of Pennsylvania for the project "METAL-MEDIATED C-H RADIOFLUORINATION FOR RAPID ACCESS TO PET IMAGING AGENTS". The project aims to develop new methods for rapidly synthesizing Fluorine-18 labeled organic molecules for Positron...
This $384,863 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program supports research to develop a novel radiotracer imaging agent for detecting Gram-positive bacterial infections associated with implanted medical devices. The key products and services to be delivered include: In vitro testing of a bivalent radiotracer agent...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $502,841 Project Grant under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program to The Regents of the University of California, operating as Lawrence Berkeley National Laboratory (LBNL). The funding will support research and development of a novel detector readout concept for monolithic scintillation detectors that enables direct digitization...
This federal Project Grant award of $185,171 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) will support research to optimize polymeric chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) agents for prostate cancer detection. The research aims to synthesize and characterize CEST MRI agents with varying charge and...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $277,033 to the University of Cincinnati to develop novel approaches for introducing radiolabeled trifluoromethyl groups into PET tracers. The key objectives are to: 1) create a general strategy to transform alkyl halides into alkyl-[11C]CF3 and alkyl-[18F]CF3...
This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides funding of $799,962 to Tripill Biotechnology, Corp. to develop radiolabeled PSMA agents with low salivary gland uptake for improved prostate cancer imaging and therapy. The key products and services to be delivered include: Constructing PSMA derivative compounds, such as NOTA-UNC-PSMA2, that can selectively reduce salivary gland uptake while maintaining high tumor uptake in prostate...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to M3D, Inc. will develop a novel gamma-ray radiation imager for image-guided tumor diagnostics. The goal is to create a system capable of rapidly and accurately detecting gamma-ray emitting radiotracers used to identify the location of lymph nodes and tumor drainage during cancer surgical procedures. The project will characterize the design parameters of the...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $275,773 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to Dropletpharm Inc., a for-profit company. The grant supports Dropletpharm's development of microfluidic technologies to enable low-cost and distributed manufacturing of radiopharmaceuticals for clinical and research applications.

Specifically, the project aims to expand Dropletpharm's droplet-based radiochemistry approach beyond 18F-radiotracers to include radiometal isotopes such as 68Ga, 64Cu, and 89Zr. Key objectives include developing radioisotope concentration methods, demonstrating droplet labeling protocols for example radiotracers, and producing [68Ga]Ga-PSMA-11 in a Good Manufacturing Practice (GMP) setting. This work builds upon Dropletpharm's prior microfluidic advancements in PET tracer synthesis and quality control. The project period runs from September 1, 2023 to August 31, 2024.

Generated 8/13/24, 9:53 AM