This federal Project Grant award of $477,129 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) supports the development and testing of a novel computed tomography (CT) contrast agent, dextran-coated cerium oxide nanoparticles (DEX-CENP), for imaging inflammatory bowel disease (IBD). The project aims to characterize several variations of DEX-CENP, evaluate their potential for CT imaging of IBD, and assess their therapeutic efficacy for treating IBD. Key deliverables include demonstrating the DEX-CENP's ability to produce strong CT contrast and accumulate in IBD-affected areas of the large intestine, as well as evaluating the safety and anti-inflammatory properties of the nanoparticles. The 4-year project, beginning January 1, 2025, is being conducted by the Trustees of the University of Pennsylvania.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $477.1k | 12/25/24 |