This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop new methods for incorporating the radioisotope fluorine-18 into complex molecules. The $174,375 award, effective December 5, 2024 through November 30, 2027, will support research at The Johns Hopkins University to explore the use of metal-centered fluorination to complement and expand existing radiochemistry techniques. The project seeks to demonstrate the suitability of various metal centers for radiopharmaceutical applications, including their pharmacological properties, multimodality capabilities, and ability to pair with therapeutic isotopes. The research will involve head-to-head comparisons of the new fluorination methods against the currently used aluminum fluoride approach for labeling prostate-specific membrane antigen (PSMA) and carbonic anhydrase IX (CAIX) targets, with the goal of translating successful techniques for future human use.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $174.4k | 12/5/24 |