Project Grant R00DE032704
Award Date
4/1/25
Completion Date
3/31/30
Dollars Obligated
$249K
Federal Agency
National Institute of Dental and Craniofacial Research
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Cambridge, MA 02142, USA
Similar Awards
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), totaling $557,606.00, supports research aimed at advancing the understanding of periodontal stem cells and their regulation for more predictable and efficient periodontal tissue regeneration. The key research objectives are to: 1) characterize the properties of periodontal crestal stem cells (PCSCs) and their activation by...
This $241,500 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121) will fund research to identify diffusible small molecules that regulate the replication of the oral bacterium Porphyromonas gingivalis (P. gingivalis). The research aims to establish the identity of growth-promoting cues produced by different strains of P. gingivalis and the early biofilm colonizer Veillonella...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $873,546 Project Grant under the Oral Diseases and Disorders Research Program (CFDA 93.121) to the University of Texas Health Science Center at Houston (UTHealth). The grant aims to develop a biomaterial-enhanced system for targeted localization of engineered probiotic bacteria (Limosilactobacillus reuteri) that secrete the anti-inflammatory cytokine interleukin-10 (IL-10) to treat experimental periodontitis. The key...
This R01 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), funded under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $1,029,581 to Virginia Commonwealth University (VCU) over a 5-year period from May 2024 to April 2029. The research will investigate two-component signaling systems in the oral pathogen Treponema denticola, which plays a key role in the progression of periodontitis, a common and destructive inflammatory...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) totals $588,952 and will run from April 2025 to March 2030. The funding will support the development and optimization of a bio-inspired tubular matrix scaffold to guide the formation of periodontal ligament (PDL) principal fibers and rebuild the microenvironment for the regeneration of Sharpey's fibers, which are critical for...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under CFDA program 93.121 Oral Diseases and Disorders Research provides $226,500.00 to The Medical University of South Carolina to investigate the role of the CD38 signaling pathway in regulating aging-associated immune responses induced by oral bacterial pathogens. The goal is to define how oral pathogens like Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis affect aging-associated...
This Project Grant award, totaling $446,875.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award supports research to investigate the role of a novel G protein-coupled receptor (MRGPRX2/MRGPRB2) expressed on mast cells and its contribution to the development of periodontal disease. The research aims to develop humanized mouse models to study the impact of this receptor and its...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $858,000 in funding to the University of Texas Health Science Center at Houston (UTHealth) from September 2024 to September 2026. The research project aims to investigate the mechanisms by which the anaerobic bacterium Veillonella inhibits the hemolytic activity of the periodontal pathogen Porphyromonas...
This Project Grant award of $565,228, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program, aims to identify cell surface markers and develop strategies for harnessing periodontal ligament stem cells (PDLSCs) to induce endogenous periodontal regeneration. The research, conducted by the University of Pittsburgh from August 2024 to May 2029, seeks to characterize the human homologs of mouse...
This Project Grant award of $1,839,472 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to define dysbiosis and identify microbial changes that are predictive of periodontitis progression and stability. The project aims to utilize the biobank and longitudinal data from the previous "Biomarkers of Periodontal Disease Progression (BPDP)" study to examine microbial,...