Project Grant R00DE032049
- This federal Project Grant award of $155,500 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to elucidate the functions of the ENPP1 enzyme and its role in regulating pyrophosphate levels to promote cementum formation. The research aims to understand how ENPP1 modulates cementogenesis through local regulation of ATP and pyrophosphate, which are critical for proper mineralization...
- This $385,116 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research on senescent periodontal ligament cells as a potential therapeutic target for age-associated periodontitis. The award to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) aims to investigate the mechanisms by which aging increases periodontal disease bone loss,...
- This federal Project Grant award of $588,952 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is funding research to develop a bio-inspired scaffold (PerióPatch) for regenerating Sharpey's fibers and the periodontal ligament (PDL). The research aims to integrate biophysical and biochemical cues into a matrix to guide PDL stem cell migration, growth, and the formation of well-aligned PDL principal and...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $639,248 Project Grant to the University of Florida to assess the marginal associations between dental caries and periodontal diseases, and their determinants, in cross-sectional studies. The research will develop statistical methodologies to address the challenge of "informative cluster size" in analyzing correlated dental...
- This $762,432 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR), part of the U.S. Department of Health and Human Services, under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant was awarded to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences), a non-profit research organization, to investigate the role of the CD73 enzyme in controlling inflammation and bone loss associated with...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $315,000 to The Ohio State University to conduct research on how aging affects the dentin-pulp complex in teeth. The key objectives are to: 1) Identify secreted bioactive proteins in dentin that change with age, and 2) Analyze age-dependent changes in teeth. This will involve extracting molars from young and old...
- The federal Project Grant award of $309,038, issued on August 8, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports the development of a novel anti-infective therapy for treating periodontitis. The project aims to develop a first-in-class inhibitor of the "red complex" bacteria (P. gingivalis, T. forsythia, and T. denticola) that are considered the causative agents of periodontitis, a...
- This federal Project Grant award of $311,000.00 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will be used by the University of Washington to conduct research to characterize the microbial and inflammatory state within distant clinically healthy tissues in patients with active periodontal disease. The research aims to increase understanding of how inflammation is triggered and maintained during the...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $432,209 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of California, Los Angeles (UCLA) for a 2-year period starting on August 1, 2023. The funding supports research to investigate the role of the CXCL10-CXCR3 axis in the compounding effects of diabetes mellitus on periodontitis. Specifically, the research aims to further elucidate the role of CXCL10 in the...
- This Project Grant award, totaling $645,009.00 and provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), aims to investigate the role of osteocytes and the nucleotide-binding oligomerization domain containing 1 (NOD1) receptor in the mechanism of alveolar bone loss associated with periodontal disease. The research, to be conducted by Augusta University Research Institute, Inc. (doing...
This $249,000 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund a 5-year research project by the University of Illinois to study the structure and biology of cementum as it relates to aging and periodontal disease. The project aims to identify the biochemical, structural, and mechanical features of cementum as it changes with age, define the state of cementum in periodontally involved teeth, and delineate in vivo mechanisms of how aging and disease impact cementum. This research seeks to advance fundamental knowledge about dental and oral health, with the goal of developing improved prevention, early detection, and treatment strategies for oral conditions across the lifespan.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 5/14/25 |